Results 41 to 50 of about 2,321,862 (234)
Thrombospondin expression in myofibers stabilizes muscle membranes
eLife, 2016 Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organization of membrane attachment complexes.
Davy Vanhoutte +13 more
openaire +3 more sources
An Epigenetic Trap Stabilizes Singular Olfactory Receptor Expression [PDF]
Cell, 2013 The molecular mechanisms regulating olfactory receptor (OR) expression in the mammalian nose are not yet understood. Here, we identify the transient expression of histone demethylase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiation and stabilization of OR expression.
Lyons, David B. +5 more
openaire +2 more sources
G3: Genes, Genomes, Genetics, 2017 While quantitative PCR (qPCR) is widely recognized as being among the most accurate methods for quantifying gene expression, it is highly dependent on the use of reliable, stably expressed reference genes.
Kimmy A. Stanton +7 more
doaj +1 more source
Reference Gene Screening for Analyzing Gene Expression Across Goat Tissue [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 Real-time quantitative PCR (qRT-PCR) is one of the important methods for investigating the changes in mRNA expression levels in cells and tissues.
Yu Zhang +6 more
doaj +1 more source
Stochastic neural network models for gene regulatory networks [PDF]
, 2003 Recent advances in gene-expression profiling technologies provide large amounts of gene expression data. This raises the possibility for a functional understanding of genome dynamics by means of mathematical modelling.
Burrage, K., Tian, T.
core +2 more sources
Guangdong nongye kexue【Objective】Real-time quantitative PCR is one of the most conventional and efficient techniques for studying the mRNA expression level of target genes. The proper selection of reference genes is of great significance for the accuracy of the results.
Benshui SHU +6 more
doaj +1 more source
Stabilization of mRNA Expression in Whole Blood Samples [PDF]
Clinical Chemistry, 2002 AbstractBackground: Accurate quantification of mRNA in whole blood is made difficult by the simultaneous degradation of gene transcripts and unintended gene induction caused by sample handling or uncontrolled activation of coagulation. This study was designed to compare a new blood collection tube (PAXgeneTM Blood RNA System) and a companion sample ...
Lynne, Rainen +10 more
openaire +2 more sources
Czech Journal of Animal Science, 2016 The microRNAs are non-coding RNA molecules of approximately 20-22 nucleotides that are found to be implicated in a wide range of physiological processes.
W.L. Bai +9 more
doaj +1 more source
A variance-stabilizing transformation for gene-expression microarray data [PDF]
Bioinformatics, 2002 Abstract Motivation: Standard statistical techniques often assume that data are normally distributed, with constant variance not depending on the mean of the data. Data that violate these assumptions can often be brought in line with the assumptions by application of a transformation.
Durbin, Blythe +3 more
openaire +3 more sources
Cezanne regulates E2F1-dependent HIF2α expression [PDF]
, 2015 Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Altun +48 more
core +4 more sources