Results 81 to 90 of about 687,469 (294)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A new Riemann–Liouville type fractional derivative operator and its application in generating functions

Advances in Difference Equations, 2018
Here, the concept of a new and interesting Riemann–Liouville type fractional derivative operator is exploited. Treatment of a fractional derivative operator has been made associated with the extended Appell hypergeometric functions of two variables and ...
M. Shadab, M. Faisal Khan, J. Luis Lopez-Bonilla   +2 more
doaj   +1 more source

Functional Dynamics of Substrate Recognition in TEM Beta-Lactamase

Entropy, 2022
The beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem.
Chris Avery, Lonnie Baker, Donald J. Jacobs   +2 more
doaj   +1 more source

Spread of wave packets in disordered hierarchical lattices

, 2017
We consider the spreading of the wave packet in the generalized Rosenzweig-Porter random matrix ensemble in the region of non-ergodic extended states ...
Abchuyeh, Mohsen Amini
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

On a new extension of extended (p,q) Beta function

University of Aden Journal of Natural and Applied Sciences
The main objective of this paper is to introduce a further extension of extended (p, q)-Beta function by considering product of two Mittag-Leffler functions in the kernel. We investigate various properties of this newly defined Beta function such as integral representations, summation formulas and Mellin transform. Further, some known and new relations
Salem Saleh Barahmah
openalex   +3 more sources

Extended Riemann-Liouville fractional derivative operator and its applications [PDF]

, 2015
Many authors have introduced and investigated certain extended fractional derivative operators. The main object of this paper is to give an extension of the Riemann-Liouville fractional derivative operator with the extended Beta function given by ...
Agarwal, Praveen, Choi, Junesang, Paris, Richard B.   +2 more
core   +1 more source

The Partition Function of Multicomponent Log-Gases

, 2011
We give an expression for the partition function of a one-dimensional log-gas comprised of particles of (possibly) different integer charge at inverse temperature {\beta} = 1 (restricted to the line in the presence of a neutralizing field) in terms of ...
Berezin F A, Boussicault A, Christopher D Sinclair, de Bruijn N G, Forrester P, Forrester P J, Halperin B I, Jokela N, Jokela N, Luque J-G, Luque J-G, Mehta M L, Meray C, Rains E M, Rider B, Selberg A, Sinclair C D, Sinclair C D   +17 more
core   +1 more source