Results 31 to 40 of about 1,653,621 (270)

Creative conceptual design: Extending the scope by infused design

Computer-Aided Design, 2009
Many methods that support human creativity by manual or computational means have been proposed in the past. They rely on the assumption that following a certain process of reasoning might lead to generating ideas considered creative. We start by defining creativity as a capability that enables the creation of systems that are patentable.
Offer Shai, Yoram Reich, Daniel Rubin
openaire   +1 more source

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations

Antibiotics, 2022
The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem.
Yu Wang, Xiaofen Liu, Kun Li, Yaxin Fan, Jicheng Yu, Hailan Wu, Yi Li, Xiaojie Wu, Beining Guo, Xin Li, Jiali Hu, Jufang Wu, Guoying Cao, Jing Zhang   +13 more
doaj   +1 more source

Rising Carbapenem MICs and Clinical Dose Optimization: Bridging Resistance Surveillance and Pharmacokinetic/Pharmacodynamic Strategies

Antibiotics
The rise in carbapenem resistance is well documented, but a less conspicuous trend has received far less attention: the gradual upward shift in minimum inhibitory concentration (MIC) values among isolates that remain phenotypically “susceptible.” We ...
Hülya Arık
doaj   +1 more source

Extended Remdesivir Infusion for Persistent Coronavirus Disease 2019 Infection

Open Forum Infectious Diseases, 2022
Abstract Persistent severe acute respiratory syndrome coronavirus 2 infection is difficult to treat. Here, we report a case of 5-month persistent coronavirus disease 2019 in an immunocompromised patient who was successfully treated with 30 consecutive days of remdesivir.
Mario A Martinez, Ting-Yi Chen, Hosoon Choi, Munok Hwang, Dhammika Navarathna, Linhue Hao, Michael Gale, Gregory Camus, Hector E Ramirez, Chetan Jinadatha   +9 more
openaire   +2 more sources

Pharmacokinetics of Meropenem in People with Cystic Fibrosis—A Proof of Concept Clinical Trial

Antibiotics, 2021
Anti-infective treatment of pulmonary exacerbations is a major issue in people with cystic fibrosis (CF). Individualized dosing strategies and adaptation of infusion times are important concepts to optimize anti-infective therapy. In this prospective non-
Jan C. Kamp, Jan Fuge, Felix C. Ringshausen, Denis Grote-Koska, Korbinian Brand, Lukas Graalmann, Ralf-Peter Vonberg, Tobias Welte, Jessica Rademacher   +8 more
doaj   +1 more source

Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Pseudomonas aeruginosa Isolates

Microbiology Spectrum, 2022
The aim of this study was to compare the efficacy of intermittent (1-h), extended (4-h), and continuous ceftolozane-tazobactam (C/T) infusion against three extensively drug-resistant (XDR) sequence type (ST) 175 P.
María Milagro Montero, Sandra Domene-Ochoa, Carla López-Causapé, Inmaculada López-Montesinos, Sonia Luque, Luisa Sorlí, Núria Campillo, Eduardo Padilla, Núria Prim, Lorena Ferrer Alapont, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Extended infusion versus intermittent infusion of Piperacillin/tazobactam: altering current methods to optimize future outcome

, 2023
Due to worldwide bacterial resistance, researchers and clinicians were required to optimize existing antimicrobials by influencing the pharmacokinetics and pharmacodynamics (PK/PD) features. Piperacillin/tazobactam (PIP/TZB) is one of the most frequently
Mohammed AlShehail, Bashayer, Alenazi, Ahmed, Alhamed, Nada, Alsultan, Mohammed M., Alabdullatif, Ammar, Aldhafeeri, Maha, Al Jamea, Zainab   +6 more
core  

Evaluation Outcomes Associated with Alternative Dosing Strategies for Piperacillin/Tazobactam: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2016
A better dosing strategy can improve clinical outcomes for patients. We systematically reviewed the literatures to determine whether any clinical benefits exist for piperacillin/tazobactam by extended or continuous infusion. Methods - A search of PubMed,
Hui Yang, Xiangli Cui, Zhuo Ma, Lihong Liu   +3 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source