Results 121 to 130 of about 5,492,450 (303)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Extensively Drug-resistant Tuberculosis, Italy and Germany

Emerging Infectious Diseases, 2007
To the Editor: Twenty-three countries have reported >1 case of extensively drug-resistant tuberculosis (XDR TB) (1); however, information about XDR TB is still incomplete. In particular, the response of XDR TB to treatment in countries with low incidence is not known. We compared mortality rates from XDR TB with those from multidrug-resistant (MDR) TB.
Migliori G. B., Ortmann J., Girardi E., Besozzi G., Lange C., Cirillo D. M., Ferrarese M., De Iaco G., Gori A., Raviglione M. C., Kirsten D., Ruesch Gerdes S., Piana F., Codecasa L. R., Lacchini C., Matteelli A., De Lorenzo S., Troupioti P., Gualano G., De Mori P., Fattorini L., Iona E., FERRARA, Giovanni, Centis R.   +23 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Drug sensitivity pattern among category –I relapse cases of pulmonary tuberculosis and its correlation with pre- treatment sputum and radiological status

MRIMS Journal of Health Sciences, 2016
Background: An increased incidence of drug resistance is seen even after active implementation of directly observed treatment short course (DOTS). Early diagnosis of such cases can be improved by performing DST (drug sensitivity test) in all relapse ...
Narendra Kumar Narahari, Sudhir Kumar Vujhini   +1 more
doaj   +1 more source

A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China. [PDF]

Nat Commun, 2022
Qiu S, Liu K, Yang C, Xiang Y, Min K, Zhu K, Liu H, Du X, Yang M, Wang L, Sun Y, Zhou H, Mahe M, Zhao J, Li S, Yu D, Hawkey J, Holt KE, Baker S, Yang J, Xu X, Song H.   +21 more
europepmc   +1 more source

Antimicrobial drug use and resistance in Europe [PDF]

, 2008
Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000–2005 and explores whether the notion that ...
Grundmann, Hajo, Goossens, Herman, Ferech, Matus, Zarb, Peter, Sande-Bruinsma, Nienke van de, Verloo, Didier, Tiemersma, Edine, Monen, Jos, European Antimicrobial Resistance Surveillance System and European Surveillance of Antimicrobial Consumption Project Groups   +8 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prevalence of extensively drug-resistant gram negative bacilli in surgical intensive care in Egypt

The Pan African Medical Journal, 2014
INTRODUCTION: the prevalence of extensively drug resistant gram negative bacilli (XDR-GNB) is rapidly progressing; however in Egypt data are sparse. We conducted the present study to quantify the incidence, risk factors and outcome of patients harboring ...
Ahmed Hasanin, Akram Eladawy, Hossam Mohamed, Yasmin Salah, Ahmed Lotfy, Hanan Mostafa, Doaa Ghaith, Ahmed Mukhtar   +7 more
doaj   +1 more source

Extensive Drug Resistance of Strong Biofilm-Producing Acinetobacter baumannii Strains Isolated from Infections and Colonization Hospitalized Patients in Southern Poland. [PDF]

Pathogens, 2023
Kasperski T, Romaniszyn D, Jachowicz-Matczak E, Pomorska-Wesołowska M, Wójkowska-Mach J, Chmielarczyk A.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source