Results 121 to 130 of about 308,220 (256)

In Vitro Cell Culture Drug Resistance Testing

, 2004
Drug development and screening programme for the identification Of a novel concer chemotherapeutic agent involves extensive preclin iCal evaluation of vast n umber Of chemicals for detection 0' their antineoplastic activity.
Mugala, Prabhavathy
core   +1 more source

Isolation, Characterization and in vitro Evaluation of Specific Bacteriophages Targeting Extensive Drug Resistance Strains of Pseudomonas aeruginosa Isolated from Septic Burn Wounds. [PDF]

Infect Chemother, 2022
Marashi SMA, Nikkhahi F, Hamedi D, Shahbazi G.   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Extensive drug-resistance in strains of Escherichia coli and Klebsiella pneumoniae isolated from paediatric urinary tract infections. [PDF]

J Taibah Univ Med Sci, 2021
Iqbal Z, Mumtaz MZ, Malik A.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

ECONOMIC FEASIBILITY OF NEW CHEMOTHERAPY REGIMENS FOR TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE

, 2018
The article presents economic feasibility evaluation for using high-priced drugs in the regimens for treatment of tuberculosis patients with extensive drug resistance.Subjects and Methods.
O. V. Lovacheva, K. A. Glebov, I. A. Vasilyeva, A. G. Samoylova, A. V. Rudakova, L. N. Chernousova   +5 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE

, 2017
The efficiency of using co-trimoxazole for treatment of mice infected with tuberculous mycobacteria with extensive drug resistance and supposed sensitivity to co-trimoxazole have been investigated.The study of 78 clinical cultures of tuberculous ...
N. A. Elistratova, T. P. Sabgayda, G. N. Mozhokina, S. A. Popov, S. A. Kosenkov   +4 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification, Antimicrobial Resistance Profiling and Virulence Factors of Bacterial Isolates Recovered from Human Clinical Cases

Journal of Pure and Applied Microbiology
Antimicrobial Resistance (AMR) among different microorganisms has become a serious issue and contributing to cause severe diseases. Proper monitoring measures should be taken to improve the current scenario of antimicrobial resistance.
Bharti Minhas, Vanshika Chandel, Naveen Minhas, Shubham Attri, Arun Singha, Vranda Thakur   +5 more
doaj   +1 more source