Results 101 to 110 of about 5,492,450 (303)

Antimicrobial susceptibility patterns of pathogens isolated from clinical specimens at a tertiary care hospital in Bangladesh, 2020–2023

The Microbe
Antimicrobial resistance has emerged as a critical issue in the medical sector globally, including in developing countries such as Bangladesh. The objective of the study was to determine the profile of bacteria and antibiotic resistance patterns of ...
Mohammad Kamruzzaman, Fahim Alam Nobel, Saiful Islam, Amiyo Haider, Mohammad Nasir Uddin, Mohammod Johirul Islam   +5 more
doaj   +1 more source

Automated plasmapheresis for management of hepatotoxic reactions to chemotherapy in pulmonary tuberculosis patients with multiple drug resistance including those with concurrent viral hepatitis

Туберкулез и болезни лёгких, 2018
The objective of the study: to assess the efficiency of therapeutic discrete automated plasmapheresis in the management of hepatotoxic reactions, developed in tuberculosis patients with multiple and extensive drug resistance, including those with ...
E. V. Vаniev, A. G. Sаmoylovа, A. E. Ergeshov, O. V. Lovаchevа, I. A. Vаsilyevа   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enteric susceptibility profile: finding hope amidst despair

Journal of the Pakistan Medical Association
Objective: To assess the overall antimicrobial susceptibility profile of enteric fever patients in a tertiary care setting. Method: The retrospective study was conducted at Pakistan Institute of Medical Sciences, Islamabad, Pakistan, and comprised ...
Ali Sufyan, Hameer Saif Talpur, Fiza Shafi, Shajee Siddiqui   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Emergence of Multidrug-Resistant, Extensively Drug-Resistant and Untreatable Gonorrhea

Future Microbiology, 2012
The new superbug Neisseria gonorrhoeae has retained resistance to antimicrobials previously recommended for first-line treatment and has now demonstrated its capacity to develop resistance to the extended-spectrum cephalosporin, ceftriaxone, the last remaining option for first-line empiric treatment of gonorrhea.
Magnus, Unemo, Robert A, Nicholas
openaire   +3 more sources

Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection [PDF]

, 2011
Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibility results and molecular strain typing data with treatment outcome ...
Rüsch-Gerdes Sabine, Jarosz T, Melzer, J, G. Orefici (7619027), Lanfranco Fattorini, Yesilkaya Hasan, F. Meacci (7619015), Checchi F, M. Bonnet (7619009), Peter W. Andrew (153608), Heinz Rinder, Rinder H, Oggioni Marco Rinaldo, Oggioni MR, Rüsch-Gerdes, S, Manuela Pardini, Melzer J, L. Fattorini (3685348), Francesca Meacci, Marco Rinaldo Oggioni, Andrew PW, Andrew, P W, Andrew P. W, Varaine F., Hasan Yesilkaya (345723), Meacci, F, Germano Orrù, Fattorini, L, Varaine, F, Varaine Francis, Orefici G, Fattorini L, Barer, Orrù Germano, Pardini M, Pardini, M, G. Orrù (7619018), Barer Mike, Andrew Peter W., Francesco Checchi, Orrù, G, M. R. Oggioni (7619033), Maryline Bonnet, Rüsch-Gerdes S, Rinder, H, T. Jarosz (7619021), Mike Barer (345729), Orefici, G, ORRU, GERMANO, Rinder Heinz, J. Melzer (7619036), Mike Barer, Meacci F, Jarosz, T, Fattorini Lanfranco, Bonnet, M, Orefici Graziella, Oggioni M. R, Graziella Orefici, Pardini Manuela, Melzer Juliet, Peter W. Andrew, Oggioni, M R, Peter W Andrew, Francis Varaine, S. Rüsch-Gerdes (7619030), Barer M, Varaine F, F. Varaine (7619042), H. Rinder (7619024), Bonnet M, Stefan Niemann, Niemann S, Jarosz Thierry, F. Checchi (5090408), Orru G, M. Pardini (7619012), Checchi Francesco, Yesilkaya H, Rusch Gerdes S, Yesilkaya, H, Checchi, F, Barer, M, Niemann Stefan, Sabine Rüsch-Gerdes, Meacci Francesca, Hasan Yesilkaya, S. Niemann (7619039), Niemann, S, Bonnet Maryline, Thierry Jarosz, Juliet Melzer   +91 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Phage-antibiotic synergy attenuates Acinetobacter baumannii resistance in refractory pneumonia: a precision therapeutic case

Frontiers in Cellular and Infection Microbiology
Extensively drug-resistant (XDR) Acinetobacter baumannii pneumonia carries severe pneumonia, respiratory failure and high mortality, showing limited therapeutic options in critically ill patients.
Lei Zhang, Lei Zhang, Kexin Yan, Pengli Xu, Yanyu Xiao, Cheng Guo, Guiqin Dai, Jie Lin, Deliang Liu, Man Rao, Zhiqiang Lin, Pengfei Zhao, Pengfei Zhao, Mingbin Zheng, Mingbin Zheng, Yang Zhou, Yang Zhou, Hongzhou Lu, Hongzhou Lu   +18 more
doaj   +1 more source

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries.
Mbugi, Erasto V, Balthazary Sakurani T, Malisa, Allen L, Mbugi Erasto V, Allen L Malisa, Nyambo, Thomas B, Nyambo, T.B., Mutayoba, B.M., Mutayoba Benezeth M, Nyambo Thomas B, Balthazary, Sakurani T, Erasto V Mbugi, Balthazary, S.T., Hassan Mshinda, Mshinda, H., Mshinda Hassan, Benezeth M Mutayoba, Sakurani T Balthazary, Malisa Allen L, Mutayoba, Benezeth M, Mbugi, E.V., Thomas B Nyambo, Mshinda, Hassan, Malisa, A.L.   +23 more
core   +1 more source