Results 91 to 100 of about 5,492,450 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]

, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Efficacy of treatment of extensive drug resistant tuberculosis in patients with different genotypes in the biotransformation enzyme genes of CYP2B6 and NAT2

Туберкулез и болезни лёгких, 2020
The objective of the study: to evaluate the efficacy of treatment of extensive drug resistant tuberculosis (XDR-TB) in patients with different genotypes in the biotransformation system NAT2 (rs1041983, rs1799930, rs1799931, rs1801280) and CYP2B6 genes ...
M. M. Yunusbаevа, L. Ya. Borodinа, F. S. Bilаlov, R. A. Shаripov, T. R. Nаsibullin, B. B. Yunusbаev   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis

Global Health Action, 2019
Background The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings.
Nana Adoma Nkansa-Gyamfi, Joseph Kazibwe, Daouda A. K. Traore, Emmanuel Nji   +3 more
doaj   +1 more source

Multidrug Resistance in Bacterial Isolates from Pus Samples: A Hospital-based Descriptive Cross-sectional Study [PDF]

National Journal of Laboratory Medicine
Introduction: Antimicrobial Resistance (AMR) is a growing public health threat. Multidrug-resistant (MDR) bacteria, initially associated with healthcare-associated infections, have now spread and become a major cause of community-acquired infections, as ...
Hemangi Dasharath Ingale
doaj   +1 more source

Implementation of a National Anti-Tuberculosis Drug Resistance Survey in Tanzania. [PDF]

, 2008
A drug resistance survey is an essential public health management tool for evaluating and improving the erformance of National Tuberculosis control programmes.
Mfaume, Saidi M, Range Nyagosya, Mfaume, Saidi M., Cobelens Frank G, Chonde Timothy M, Mfinanga Sayoki GM, Egwaga Saidi M, Lwilla, F., Mfinanga, Sayoki G M, van Leth, Frank, Zignol, M., van Leth, F., Doulla Basra, Van Deun, A., Mfaume, S. M., Doulla, Basra, Range, Nyagosya, Mfaume Saidi M, van Deun Armand, Chonde, Timothy M, Range, N., Mfinanga, S. G. M., Chonde, Timothy M., van Leth Frank, Cobelens, F. G., van Deun, Armand, Egwaga, Saidi M, Cobelens, Frank G., Lwilla Fred, Chonde, T. M., Zignol Matteo, Egwaga, S. M., Mfinanga, Sayoki G. M., Doulla, B., Cobelens, Frank G, Egwaga, Saidi M., Zignol, Matteo, Lwilla, Fred   +37 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source