Results 71 to 80 of about 308,220 (256)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance

, 2008
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
core  

Genotypic and epidemiological characterization of Mycobacterium tuberculosis complex in Ghana [PDF]

, 2015
Tuberculosis (TB) remains a public health challenge. In 2013, TB was estimated to have caused 9 million incident cases of which 1.1 million were co infected with HIV and 1.5 million deaths worldwide. For the effective control of TB, the use of simplified
Asante-Poku, Adwoa
core   +1 more source

Multidrug Resistance in Bacterial Isolates from Pus Samples: A Hospital-based Descriptive Cross-sectional Study [PDF]

National Journal of Laboratory Medicine
Introduction: Antimicrobial Resistance (AMR) is a growing public health threat. Multidrug-resistant (MDR) bacteria, initially associated with healthcare-associated infections, have now spread and become a major cause of community-acquired infections, as ...
Hemangi Dasharath Ingale
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Automated plasmapheresis for management of hepatotoxic reactions to chemotherapy in pulmonary tuberculosis patients with multiple drug resistance including those with concurrent viral hepatitis

Туберкулез и болезни лёгких, 2018
The objective of the study: to assess the efficiency of therapeutic discrete automated plasmapheresis in the management of hepatotoxic reactions, developed in tuberculosis patients with multiple and extensive drug resistance, including those with ...
E. V. Vаniev, A. G. Sаmoylovа, A. E. Ergeshov, O. V. Lovаchevа, I. A. Vаsilyevа   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Transferable drug resistance plasmids in fish-pathogenic bacteria

, 2000
Chemotherapeutic agents have been developed for treating bacterial infections and have been widely used for cultured fish for the last 30 years in Japan.
Aoki, Takashi
core