Results 41 to 50 of about 308,220 (256)

Occupational Rehabilitation Following Surgery for Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis

Инновационная медицина Кубани
Objective: To assess the level of occupational rehabilitation among patients who underwent surgery for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the long-term period compared with patients who refused surgery and ...
S. S. Saenko, D. B. Giller, G. V. Shcherbakova, O. Sh. Kesaev, V. V. Koroev, I. I. Martel, I. I. Enilenis, Z. V. Alborova, S. V. Smerdin, A. E. Ergeshov   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The HIV-1 Subtype C Epidemic in South America Is Linked to the United Kingdom [PDF]

, 2010
Background: The global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of ...
Gifford, RJ, Gifford Robert J., Pillay Deenan, Pillay, D, Tulio de Oliveira, UK Collaborative Grp HIV Drug Resi, Robert J Gifford, Deenan Pillay, de Oliveira, T, UK Collaborative Group on HIV Drug Resistance, de Oliveira Tulio   +10 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection

, 2011
Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibility results and molecular strain typing data with treatment outcome ...
Rüsch-Gerdes Sabine, Jarosz T, Melzer, J, G. Orefici (7619027), Lanfranco Fattorini, Yesilkaya Hasan, F. Meacci (7619015), Checchi F, M. Bonnet (7619009), Peter W. Andrew (153608), Heinz Rinder, Rinder H, Oggioni Marco Rinaldo, Oggioni MR, Rüsch-Gerdes, S, Manuela Pardini, Melzer J, L. Fattorini (3685348), Francesca Meacci, Marco Rinaldo Oggioni, Andrew PW, Andrew, P W, Andrew P. W, Varaine F., Hasan Yesilkaya (345723), Meacci, F, Germano Orrù, Fattorini, L, Varaine, F, Varaine Francis, Orefici G, Fattorini L, Barer, Orrù Germano, Pardini M, Pardini, M, G. Orrù (7619018), Barer Mike, Andrew Peter W., Francesco Checchi, Orrù, G, M. R. Oggioni (7619033), Maryline Bonnet, Rüsch-Gerdes S, Rinder, H, T. Jarosz (7619021), Mike Barer (345729), Orefici, G, ORRU, GERMANO, Rinder Heinz, J. Melzer (7619036), Mike Barer, Meacci F, Jarosz, T, Fattorini Lanfranco, Bonnet, M, Orefici Graziella, Oggioni M. R, Graziella Orefici, Pardini Manuela, Melzer Juliet, Peter W. Andrew, Oggioni, M R, Peter W Andrew, Francis Varaine, S. Rüsch-Gerdes (7619030), Barer M, Varaine F, F. Varaine (7619042), H. Rinder (7619024), Bonnet M, Stefan Niemann, Niemann S, Jarosz Thierry, F. Checchi (5090408), Orru G, M. Pardini (7619012), Checchi Francesco, Yesilkaya H, Rusch Gerdes S, Yesilkaya, H, Checchi, F, Barer, M, Niemann Stefan, Sabine Rüsch-Gerdes, Meacci Francesca, Hasan Yesilkaya, S. Niemann (7619039), Niemann, S, Bonnet Maryline, Thierry Jarosz, Juliet Melzer   +91 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections [PDF]

, 2008
Tuberculosis remains the most common cause of death due to a single infective organism. Despite the availability of a vaccine and chemotherapeutic options, the global disease burden remains relatively unaffected.
Willcox, Benjamin, Gurdyal S Besra, Bhatt, Apoorva; id_orcid, Dover, LG, Apoorva Bhatt, Dover, Lynn, Besra, Gurdyal; id_orcid, Besra, Gurdyal, Bhatt, Apoorva, Lynn G Dover, Bhowruth, Veemal, Veemal Bhowruth, Benjamin E Willcox   +12 more
core   +1 more source

Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

Туберкулез и болезни лёгких, 2015
The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV ...
Yu. V. Reshetnikova, S. N. Аndreevskaya, E. E. Larionova   +2 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

, 2020
The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat giardiasis, metronidazole and albendazole, is a clinical issue of growing
Arguello-Garcia, Raul, David Leitsch, Tina Skinner-Adams, Guadalupe Ortega-Pierres, M, M. Guadalupe Ortega-Pierres, Leitsch, David, Skinner-Adams, Tina, Raúl Argüello-García   +7 more
core   +1 more source