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Transmission is a key driver of extensively drug-resistant tuberculosis
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Extensively Drug-resistant Tuberculosis
The American Journal of Medicine, 2008Extensively drug-resistant tuberculosis (XDR-TB) is defined as Mycobacterium tuberculosis infection that is resistant to isoniazid, rifampin, any fluoroquinolone, and any injectable drug (amynoglicosides or polypetides). Although initially described in South Africa, it has emerged as a global threat, and cases have been reported from several countries,
Miguel G, Madariaga +2 more
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Multi-Drug Resistant and Extensively-Drug Resistant Tuberculosis
The Indian Journal of Pediatrics, 2020India is one of the high burden countries for tuberculosis (TB) including multi-drug resistant TB (MDR-TB) and extensively-drug resistant (XDR) TB. Drug-resistant (DR) TB has threatened the TB care and is a major health problem in many countries; treatment of DR TB has been difficult requiring use of reserve or second-line drugs, cost factors, has ...
Ira, Shah +2 more
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Cutaneous Extensively Drug-Resistant Tuberculosis
The American Journal of Tropical Medicine and Hygiene, 2007A 48-year-old immunocompetent man without known exposure to tuberculosis had a > 10-year history of recurrent skin lesions. Cutaneous tuberculosis without any current or past history of pulmonary tuberculosis was diagnosed. Culture of biopsy specimens showed the organism to be resistant to multiple first-line and second-line agents.
Douglas P, Olson +4 more
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Controlling extensively drug-resistant tuberculosis
The Lancet, 2007Recent successes in the fight against tuberculosis rely on short-course chemotherapy with our two most powerful drugs isoniazid and rifampicin. Unfortunately not only do hundreds of thousands of people or more still die every year of curable tuberculosis1 but inadequate treatment has also contributed to the origination of strains of tuberculosis ...
Travis C, Porco, Wayne M, Getz
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Multidrug and extensively drug-resistant tuberculosis
Médecine et Maladies Infectieuses, 2017The emergence of drug-resistant tuberculosis (TB) compromises global tuberculosis control. The incidence of multidrug-resistant strains (MDR) defined as resistant to the two main antituberculosis drugs, rifampicin and isoniazid, was raised in the 1990s.
Maitre, Thomas +10 more
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Delamanid for Extensively Drug-Resistant Tuberculosis
New England Journal of Medicine, 2015Therapeutic options for extensively drug-resistant tuberculosis infection are limited. In this post-hoc analysis, a new drug, delamanid, shows some activity in the treatment of XDR-TB.
Rajesh, Gupta +5 more
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Extensively Drug-Resistant Tuberculosis
2014It has been many years since a single agent was recommended for treatment of active tuberculosis (TB). Despite this, there is strong evidence that multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are present in all regions of the world, and there is also evidence that the incidence of drug-resistant forms of TB is increasing ...
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