Results 1 to 10 of about 481,952 (302)
Extracellular ATP/adenosine dynamics in the brain and its role in health and disease [PDF]
Frontiers in Cell and Developmental Biology, 2023 Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic injury upregulate these neuromodulators, which exert their effects by ...
Eiji Shigetomi +5 more
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The circadian regulation of extracellular ATP. [PDF]
Purinergic Signal, 2023 AbstractExtracellular ATP is a potent signaling molecule released from various cells throughout the body and is intimately involved in the pathophysiological functions of the nervous system and immune system by activating P2 purinergic receptors.
Wang X +6 more
europepmc +3 more sources
An Improved Ratiometric FRET Biosensor with Higher Affinity for Extracellular ATP [PDF]
SensorsAdenosine triphosphate (ATP) is readily released into the extracellular space as an autocrine and paracrine purinergic signaling molecule. We originally reported a genetically encoded, fluorescent protein-based Förster Resonance Energy Transfer (FRET ...
Autumn Cholger +5 more
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Computational prediction and in vitro analysis of the potential ligand binding site within the extracellular ATP receptor, P2K2 [PDF]
Plant Signaling & Behavior, 2023 The plant extracellular ATP (eATP) receptor, P2K2, binds eATP with strong ligand affinity through its extracellular lectin domain. Ligand binding activates the intracellular kinase domain of P2K2 resulting in a variety of intracellular responses and ...
Sung-Hwan Cho +3 more
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Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease [PDF]
Scientific ReportsSteatotic liver disease (SLD) is a burgeoning health problem predominantly associated with excessive alcohol consumption, which causes alcohol-related liver disease (ALD), and high caloric intake, which results in metabolic dysfunction-associated SLD ...
Tomoko Tokumaru +12 more
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Phosphate-deprivation and damage signalling by extracellular ATP. [PDF]
Front Plant Sci, 2022 Phosphate deprivation compromises plant productivity and modulates immunity. DAMP signalling by extracellular ATP (eATP) could be compromised under phosphate deprivation by the lowered production of cytosolic ATP and the need to salvage eATP as a nutritional phosphate source.
Matthus E, Ning Y, Shafiq F, Davies JM.
europepmc +5 more sources
Bio-Protocol, 2021 Adenosine 5’-triphosphate (ATP) works as an extracellular signaling molecule for cells in the brain, such as neurons and glia. Cellular communication via release of ATP is involved in a range of processes required for normal brain functions, and aberrant
Nami Kitajima +7 more
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Frontiers in Cellular Neuroscience, 2021 Small alterations in the level of extracellular H+ can profoundly alter neuronal activity throughout the nervous system. In this study, self-referencing H+-selective microelectrodes were used to examine extracellular H+ fluxes from individual astrocytes.
Ji-in Vivien Choi +13 more
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KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion. [PDF]
PLoS ONE, 2015 Our previous work has demonstrated that islet depolarization with KCl opens connexin36 hemichannels in β-cells of mouse pancreatic islets allowing the exchange of small metabolites with the extracellular medium.
Javier Pizarro-Delgado +4 more
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Optical ATP biosensor for extracellular ATP measurement [PDF]
Biosensors and Bioelectronics, 2013 Extracellular Adenosine-5'-triphosphate (ATP) is an important multi-functional molecule which can mediate numerous physiological activities by activating purinergic P2 receptors. The objective of this study was to develop a novel optical ATP sensor for in-situ extracellular ATP measurement in biological tissues.
C, Wang, C-Y C, Huang, W-C, Lin
openaire +2 more sources