Results 1 to 10 of about 302,924 (260)
Extracellular ATP/adenosine dynamics in the brain and its role in health and disease [PDF]
Frontiers in Cell and Developmental Biology, 2023 Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic injury upregulate these neuromodulators, which exert their effects by ...
Eiji Shigetomi +5 more
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The circadian regulation of extracellular ATP. [PDF]
Purinergic Signal, 2023 AbstractExtracellular ATP is a potent signaling molecule released from various cells throughout the body and is intimately involved in the pathophysiological functions of the nervous system and immune system by activating P2 purinergic receptors.
Wang X +6 more
europepmc +3 more sources
An Improved Ratiometric FRET Biosensor with Higher Affinity for Extracellular ATP [PDF]
SensorsAdenosine triphosphate (ATP) is readily released into the extracellular space as an autocrine and paracrine purinergic signaling molecule. We originally reported a genetically encoded, fluorescent protein-based Förster Resonance Energy Transfer (FRET ...
Autumn Cholger +5 more
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Computational prediction and in vitro analysis of the potential ligand binding site within the extracellular ATP receptor, P2K2 [PDF]
Plant Signaling & Behavior, 2023 The plant extracellular ATP (eATP) receptor, P2K2, binds eATP with strong ligand affinity through its extracellular lectin domain. Ligand binding activates the intracellular kinase domain of P2K2 resulting in a variety of intracellular responses and ...
Sung-Hwan Cho +3 more
doaj +2 more sources
Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease [PDF]
Scientific ReportsSteatotic liver disease (SLD) is a burgeoning health problem predominantly associated with excessive alcohol consumption, which causes alcohol-related liver disease (ALD), and high caloric intake, which results in metabolic dysfunction-associated SLD ...
Tomoko Tokumaru +12 more
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Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation [PDF]
British Journal of Pharmacology, 2004 Transient accumulation of extracellular ATP reflects both release of ATP from intracellular stores and altered rates of ATP metabolism by ecto‐enzymes. Ecto‐nucleoside triphosphate diphosphohydrolases (eNTPDases) and ecto‐nucleotide pyrophosphatases (eNPPs) degrade ATP, while ecto‐nucleotide diphosphokinases (eNDPKs) synthesize ATP from ambient ADP ...
George Dubyak
exaly +3 more sources
Extracellular ATP acts as a damage associated molecular pattern (DAMP) signal in plants
Frontiers in Plant Science, 2014 As sessile organisms, plants have evolved effective mechanisms to protect themselves from environmental stresses. Damaged (i.e., wounded) plants recognize a variety of endogenous molecules as danger signals, referred to as damage-associated molecular ...
Kiwamu eTanaka +3 more
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Frontiers in Pharmacology, 2017 Extracellular ATP is among molecules promoting microglia activation and inducing the release of extracellular vesicles (EVs), which are potent mediators of intercellular communication between microglia and the microenvironment.
Francesco Drago +11 more
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Bio-Protocol, 2021 Adenosine 5’-triphosphate (ATP) works as an extracellular signaling molecule for cells in the brain, such as neurons and glia. Cellular communication via release of ATP is involved in a range of processes required for normal brain functions, and aberrant
Nami Kitajima +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Small alterations in the level of extracellular H+ can profoundly alter neuronal activity throughout the nervous system. In this study, self-referencing H+-selective microelectrodes were used to examine extracellular H+ fluxes from individual astrocytes.
Ji-in Vivien Choi +13 more
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