Results 41 to 50 of about 481,952 (302)

Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
ATP has broad functions as an autocrine/paracrine molecule. The mode of ATP release and its intracellular source, however, are little understood. Here we show that bradykinin via B2-receptor stimulation induces the extracellular release of ATP via the ...
Yumei Zhao, Keisuke Migita, Chiemi Sato, Sadaharu Usune, Takahiro Iwamoto, Takeshi Katsuragi   +5 more
doaj   +1 more source

Extracellular ATP induces albuminuria in pregnant rats [PDF]

Nephrology Dialysis Transplantation, 2010
As circulating plasma ATP concentrations are increased in pre-eclampsia, we tested whether increased plasma ATP is able to induce albuminuria during pregnancy.Pregnant (day 14) and non-pregnant rats were infused with ATP (3000 microg/kg bw) via a permanent jugular vein cannula.
Faas, M.M., van der Schaaf, G., Borghuis, T., Jongman, R.M., van Pampus, Maria, de Vos, P., van Goor, Harry, Bakker, W.W.   +7 more
openaire   +3 more sources

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2016
Adenosine triphosphate (ATP) plays an important role as a primary molecule for the transfer of chemical energy to drive biological processes. ATP also functions as an extracellular signaling molecule in a diverse array of eukaryotic taxa in a conserved ...
Theodore W. Peters, Aaron W. Miller, Cendrine Tourette, Hannah Agren, Alan Hubbard, Robert E. Hughes   +5 more
doaj   +1 more source

Release of ATP from marginal cells in the cochlea of neonatal rats can be induced by changes in extracellular and intracellular ion concentrations. [PDF]

PLoS ONE, 2012
BackgroundAdenosine triphosphate (ATP) plays an important role in the cochlea. However, the source of ATP and the mechanism by which it is released remain unclear.
Yating Peng, Jie Chen, Shan He, Jun Yang, Hao Wu   +4 more
doaj   +1 more source

Homeostasis of Extracellular ATP in Human Erythrocytes [PDF]

Journal of Biological Chemistry, 2011
استكشفنا العمليات داخل وخارج الخلايا التي تحكم حركية ATP خارج الخلايا (ATPe) في كريات الدم الحمراء البشرية المحفزة بالعوامل التي تزيد من المخيم. باستخدام تفاعل لوسيفيرين- لوسيفيراز في قياس الإضاءة خارج الخط، وجدنا تنشيطًا مباشرًا لأنزيم الأدينيل سايكلز بواسطة فورسكولين وتنشيطًا غير مباشر من خلال التحفيز الأدرينالي بيتا مع [ATP]e المعزز بالإيزوبروتينول ...
Nicolás Montalbetti, María Florencia Leal Denis, Omar P. Pignataro, Eiry Kobatake, Eduardo R. Lazarowski, Pablo J. Schwarzbaum   +5 more
openaire   +2 more sources

Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity [PDF]

, 2015
Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix.
Arnett, T R, Hajjawi, M O R, Key, M L, Millan, J L, Orriss, I R   +4 more
core   +2 more sources

c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells ^†

Cells, 2020
Angiogenic vasa vasorum (VV) expansion plays an essential role in the pathogenesis of hypoxia-induced pulmonary hypertension (PH), a cardiovascular disease.
Derek Strassheim, Vijaya Karoor, Hala Nijmeh, Philip Weston, Martin Lapel, Jerome Schaack, Timothy Sullivan, Edward C. Dempsey, Kurt R. Stenmark, Evgenia Gerasimovskaya   +9 more
doaj   +1 more source

Hepatocyte heterogeneity in response to extracellular ATP [PDF]

European Journal of Biochemistry, 1987
The metabolic and hemodynamic effects of extracellular ATP in perfused rat liver were compared during physiologically antegrade (portal to hepatic vein) and retrograde (hepatic to portal vein) perfusion. ATP in concentrations up to 100 μM was completely hydrolyzed during a single liver passage regardless of the perfusion direction.
D, Häussinger, T, Stehle, W, Gerok, T A, Tran-Thi, K, Decker   +4 more
openaire   +2 more sources

Biosensor measurement of purine release from cerebellar cultures and slices [PDF]

, 2010
We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Wall, Mark J., Eason, Robert, Dale, Nicholas   +2 more
core   +2 more sources