Results 51 to 60 of about 481,952 (302)
Bio-Protocol, 2019 Extracellular ATP is a potent signaling molecule that stimulates intracellular calcium responses through purinergic (P2) receptors in mammalian cells. While extracellular ATP and intracellular calcium can be measured separately, simultaneous monitoring ...
Nicholas Mikolajewicz, Svetlana Komarova
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Extracellular ATP: A Feasible Target for Cancer Therapy [PDF]
Cells, 2020 Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells. ATP can be released from cells via both specific and nonspecific
Valentina Vultaggio-Poma +2 more
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Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts [PDF]
, 2019 © 2019 Published by Elsevier Inc.Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, inthe medial layer of the arteries.
Arnett, Timothy R +6 more
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Glucose metabolism and oscillatory behavior of pancreatic islets [PDF]
, 2005 A variety of oscillations are observed in pancreatic islets.We establish a model, incorporating two oscillatory systems of different time scales: One is the well-known bursting model in pancreatic beta-cells and the other is the glucose-insulin feedback ...
A. L. Hodgkin +19 more
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PLoS ONE, 2008 BackgroundThere is growing awareness that tumour cells build up a "self-advantageous" microenvironment that reduces effectiveness of anti-tumour immune response.
Patrizia Pellegatti +5 more
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Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation [PDF]
British Journal of Pharmacology, 2004 Transient accumulation of extracellular ATP reflects both release of ATP from intracellular stores and altered rates of ATP metabolism by ecto‐enzymes. Ecto‐nucleoside triphosphate diphosphohydrolases (eNTPDases) and ecto‐nucleotide pyrophosphatases (eNPPs) degrade ATP, while ecto‐nucleotide diphosphokinases (eNDPKs) synthesize ATP from ambient ADP ...
Sheldon M, Joseph +3 more
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Extracellular cysteine in connexins: Role as redox sensors [PDF]
, 2016 Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D. +7 more
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Allosteric modulation of GABAA receptors by extracellular ATP [PDF]
Molecular Brain, 2014 Background: The γ-aminobutyric acid type A receptor (GABAAR) is the primary receptor mediating fast synaptic inhibition in the brain and plays a critical role in modulation of neuronal excitability and neural networks. Previous studies have demonstrated that ATP and its nucleotide analogs may regulate the function of GABAARs via Ca²⁺-dependent ...
Liu, Jun, Wang, Yu T
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Purinergic Signaling in Ovarian Carcinoma [PDF]
Advanced Pharmaceutical BulletinOvarian carcinoma (OC) is the most lethal gynecological cancer worldwide. Around 95% of patients exhibit recurrence five years after treatment; 80% experience recurrence within 18 months after first-line treatment, and progression-free survival rates ...
Angélica Sofía Martínez-Ramírez +4 more
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