Results 1 to 10 of about 2,813,323 (292)

DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology

Journal of Extracellular Vesicles, 2019
Extracellular vesicles have the capacity to transfer lipids, proteins, and nucleic acids between cells, thereby influencing the recipient cell’s phenotype.
Elisa Lázaro-Ibáñez, Cecilia Lässer, Ganesh Vilas Shelke, Rossella Crescitelli, Su Chul Jang, Aleksander Cvjetkovic, Anaís García-Rodríguez, Jan Lötvall   +7 more
doaj   +3 more sources

Clearance of extracellular DNA prevents senescence-associated antitumor immunity [PDF]

Frontiers in Immunology
BackgroundTumor tissues are characterized by high tumor cell turnover, driven by oncogenic proliferation and counteracted by tumor-suppressive mechanisms such as apoptosis and senescence.
Yong Wang, Yong Wang, Lijia Yuan, Lijia Yuan, Mingzhu Zhu, Mengyao Li, Qingru Lin, Yuqian Zhang, Yuqian Zhang, Mengwei Li, Xueyan Liu, Shun Li, Shun Li   +12 more
doaj   +2 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients [PDF]

Advanced Science
Mature red blood cells (RBCs), the most abundant anucleate cells in humans, have long been overlooked as DNA carriers. Recent evidence implicates RBC‐derived DNA (rbcDNA) as a potential biomarker for cancer diagnostics, yet its origin and how RBCs ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
doaj   +2 more sources

Extracellular DNA in blood: an index of in vivo inflammatory response

Медицинская иммунология, 2022
Increased concentration of cell-free DNA (cfDNA) in the circulating blood of humans and animals is a sign of inflammatory conditions and a distinctive characteristic of various pathophysiological processes in the body. The aim of the present study was to
E. N. Demchenko, E. D. Gavrilova, E. V. Goiman, N. N. Volskiy, O. P. Kolesnikova, V. A. Kozlov   +5 more
doaj   +1 more source

Extracellular vesicles: An emerging platform in gram-positive bacteria

Microbial Cell, 2020
Extracellular vesicles (EV), also known as membrane vesicles, are produced as an end product of secretion by both pathogenic and non-pathogenic bacteria.
Swagata Bose, Shifu Aggarwal, Durg Vijai Singh, Narottam Acharya   +3 more
doaj   +1 more source

Lack of immunogenicity of xenogeneic DNA from porcine biomaterials

Surgery Open Science, 2022
Background: Clinically useful biomaterials are derived from xenogeneic extracellular matrices, but extensive processes often used to remove all residual DNA are detrimental to their proper biological function. We hypothesized that deliberate and repeated
Rae D. Record Ritchie, PhD, Sharon L. Salmon, BSc, Michael C. Hiles, PhD, Dennis W. Metzger, PhD   +3 more
doaj   +1 more source

Extracellular dGMP enhances Deinococcus radiodurans tolerance to oxidative stress. [PDF]

PLoS ONE, 2013
Free extracellular DNA provides nutrition to bacteria and promotes bacterial evolution by inducing excessive mutagenesis of the genome. To understand the influence of extracellular DNA fragments on D. radiodurans, we investigated cell growth and survival
Mingfeng Li, Hongxing Sun, Qiong Feng, Huiming Lu, Ye Zhao, Hui Zhang, Xin Xu, Jiandong Jiao, Liangyan Wang, Yuejin Hua   +9 more
doaj   +1 more source

Collection and storage of DNA-containing biomaterial and isolated DNA

Кардиоваскулярная терапия и профилактика, 2020
The advances of biomedicine include the new technologies, diagnosis and treatment techniques, as well as the practical use of new types of biological targets, in particular, nucleic acids.
Yu. V. Doludin, A. S. Limonova, V. A. Kozlova, A. I. Efimova, A. L. Borisova, A. N. Meshkov, M. S. Pokrovskaya, O. M. Drapkina   +7 more
doaj   +1 more source

Combination of DNA Molecular Biomarkers in the Prediction of Critical Illness Outcome

Общая реаниматология, 2019
Purpose: to determine the informative value of the prediction of mortality of patients with sepsis using a combination of candidate markers — the quantitative content of circulating cell-free DNA (cfDNA) in plasma and allelic variants of TLR9 gene ...
V. M. Pisarev, A. G. Chumachenko, A. D. Filev, E. S. Ershova, S. V. Kostyuk, N. N. Veiko, E. K. Grigoriev, E. V. Elysina, R. A. Cherpakov, A. V. Tutelyan   +9 more
doaj   +1 more source

Increase of Neutrophil Extracellular Traps, Mitochondrial DNA and Nuclear DNA in Newly Diagnosed Type 1 Diabetes Children but Not in High-Risk Children

Frontiers in Immunology, 2021
Neutrophil extracellular traps (NETs) and mitochondrial DNA (mtDNA) are inflammatory mediators involved in the development of type 1 diabetes (T1D). Pancreas-infiltrating neutrophils can release NETs, contributing to the inflammatory process.
Camilla Skoglund, Daniel Appelgren, Ingela Johansson, Rosaura Casas, Johnny Ludvigsson, Johnny Ludvigsson   +5 more
doaj   +1 more source