Extracellular DNA traps promote thrombosis [PDF]
Proceedings of the National Academy of Sciences, 2010 Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes are immobilized in NETs and encounter a locally high and lethal concentration of effector proteins.
Fuchs, T. A. +9 more
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Neutrophil extracellular traps in inflammatory disorders [PDF]
, 2014 A novel feature of polymorphonuclear granulocyte (PMN) biology is their ability to generate neutrophil extracellular traps (NETs) via a distinct process of cell death termed NETosis.
Sur Chowdhury, Chanchal
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Distribution of extracellular DNA in Listeria monocytogenes biofilm
Czech Journal of Food Sciences, 2019 Extracellular DNA (eDNA) is an abundant matrix component that protects biofilm from environmental stress, facilitate horizontal gene transfer, and serve as a source of nutrients.
Martina Šuláková +3 more
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Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms. [PDF]
PLoS Pathogens, 2008 Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of DNA, bacterial polysaccharides and proteins, which are up to 1000-fold more antibiotic resistant than planktonic cultures.
Heidi Mulcahy +2 more
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Isolation and Quantification of Extracellular DNA from Biofluids
Bio-Protocol, 2020 Extracellular DNA is studied as a diagnostic biomarker, but also as a factor involved in the pathophysiology of several diseases due to its pro-inflammatory properties.
Ľubica Janovičová +3 more
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Release and persistence of extracellular DNA in the environment [PDF]
Environmental Biosafety Research, 2007 The introduction of genetically modified organisms (GMOs) has called for an improved understanding of the fate of DNA in various environments, because extracellular DNA may also be important for transferring genetic information between individuals and species.
K. M. Nielsen +3 more
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Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages [PDF]
, 2002 During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J +15 more
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EXTRACELLULAR DNA AND THE LEVEL OF ITS METHYLATION IN DIFFERENT RHEUMATIC DISEASES
Научно-практическая ревматология, 2012 Objective: to study the qualitative and quantitative composition of serum extracellular DNA (exDNA); apoptotic (nucleosomes) and necrotic fragmentation; complexification of monometinic proteins with exDNA; and the levels of exDNA methylation as compared ...
N O Shubayeva +4 more
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NADPH oxidase-independent formation of extracellular DNA traps by basophils [PDF]
, 2014 Basophils are primarily associated with a proinflammatory and immunoregulatory role in allergic diseases and parasitic infections. Recent studies have shown that basophils can also bind various bacteria both in the presence and the absence of opsonizing ...
Simon, Hans-Uwe +21 more
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Frontiers in Immunology, 2022 Bullous pemphigoid (BP) is an autoimmune disease characterized by autoantibody-mediated activation of immune cells and subepidermal blister formation. Excess amounts of extracellular DNA are produced in BP, however, it remains unclear how extracellular ...
Yuka Mizuno +6 more
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