Results 21 to 30 of about 2,813,323 (292)

Microparticles as a source of extracellular DNA [PDF]

Immunologic Research, 2010
Microparticles are small membrane-bound vesicles that display pro-inflammatory and pro-thrombotic activities important in the pathogenesis of a wide variety of diseases. These particles are released from activated and dying cells and incorporate nuclear and cytoplasmic molecules for extracellular export. Of these molecules, DNA is a central autoantigen
David S, Pisetsky, Julie, Gauley, Anirudh J, Ullal   +2 more
openaire   +2 more sources

Extracellular DNA: A Bridge to Cancer [PDF]

Cancer Research, 2015
Abstract DNase I is a secreted enzyme whose function has been presumed to control “waste management” in the human system, by degrading DNA that leaks from dead and dying cells. Emerging studies have instead yielded evidence that DNase I plays a central role in newly defined dynamics of immune and autoimmune diseases, as well as cancer ...
Martha C, Hawes, Fushi, Wen, Emad, Elquza   +2 more
openaire   +2 more sources

Multiple Origins of Extracellular DNA Traps [PDF]

Frontiers in Immunology, 2021
Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms present in protozoa, plants, and animals. In this review, we compare their similarities in species of different taxa, and put forward the hypothesis that ETs have multiple origins.
Edgar Ramos-Martínez, Leticia Hernández-González, Iván Ramos-Martínez, Laura Pérez-Campos Mayoral, Georgina I. López-Cortés, Eduardo Pérez-Campos, Eduardo Pérez-Campos, Gabriel Mayoral Andrade, María Teresa Hernández-Huerta, Marco V. José   +9 more
openaire   +3 more sources

Advantageous Antibody Microarray Fabrication Through DNA-Directed Immobilization: A Step Toward Use of Extracellular Vesicles in Diagnostics [PDF]

, 2020
An optimized general protocol for DNA-protein ligation is provided and the conjugates are used to convert DNA arrays into antibody microarrays. Arrays obtained through DDI were used to capture and characterize extracellular vesicles (EVs), an emerging ...
Marcella, Chiari, Laura, Sola, Dario, Brambilla   +2 more
core   +2 more sources

Plant Perceptions of Extracellular DNA and RNA [PDF]

Molecular Plant, 2016
Plants and microbes interact in a myriad of ways in terrestrial ecosystems, which span from molecular to open-field scales. The basis of such communications among and within species is of intense interest among the plant–biotic interactions research community.
Abhayprasad, Bhat, Choong-Min, Ryu
openaire   +2 more sources

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]

, 2013
Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Szabó, László, Szab , L., Hoell, Armin, Kolev, Krasimir, Sótonyi, Péter, Longstaff, C., Longstaff C, Krumrey, M., Komorowicz, E., Longstaff, Colin, Varjú, Imre, Kolev, K., Varga, Z., Kolev, Kraszimir Nikolaev, Komorowicz, Erzsébet, Krumrey, Michael, Hoell A, S tonyi, P., Krumrey M, Varju, I., Hoell, A., Bóta, Attila, Varga, Zoltán, B ta, A.   +23 more
core   +1 more source

The role of extracellular DNA in <i>Neisseria</i> biofilms. [PDF]

J Bacteriol
ABSTRACT The genus Neisseria includes two human pathogens, Neisseria gonorrhoeae and Neisseria meningitidis , in addition to commensal ...
Pan J, Williamson A.
europepmc   +3 more sources

Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization

Advanced Science, 2022
Although deoxyribonucleic acid (DNA) is the genetic coding for the very essence of life, these macromolecules or components thereof are not necessarily lost after a cell dies.
Min‐juan Shen, Kai Jiao, Chen‐yu Wang, Hermann Ehrlich, Mei‐chen Wan, Dong‐xiao Hao, Jing Li, Qian‐qian Wan, Lige Tonggu, Jian‐fei Yan, Kai‐yan Wang, Yu‐xuan Ma, Ji‐hua Chen, Franklin R. Tay, Li‐na Niu   +14 more
doaj   +1 more source

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]

, 2013
Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Szabó, Tamas G, Szabó, Tamás G., Buzás, Edit Irén, Lötvall, Jan, Jan Lötvall, Lässer, Cecilia, Dianzani, Irma, Irma Dianzani, Edit I. Buzás, Jan Lötvall, Buzás, Edit I, Maria Eldh, Crescitelli, Rossella, Kittel, Ágnes, Eldh, Maria, Rossella Crescitelli, Agnes Kittel, Tamas G. Szabó, Edit I. Buzás, Cecilia Lässer, Tamas G. Szabó, Cecilia Lässer, Eldh, Maria,, Lässer, Cecilia,, Lötvall, Jan,, Crescitelli, Rossella,   +25 more
core   +1 more source

Extracellular DNA includes an important fraction of high-risk antibiotic resistance genes in treated wastewaters

, 2023
Wastewater treatment plants are among the main hotspots for the release of antibiotic resistance genes (ARGs) into the environment. ARGs in treated wastewater can be found in the intracellular DNA (iDNA) and in the extracellular DNA (eDNA). In this study,
Sbaffi Tomasa, Corno Gianluca, Raffaella Sabatino, Andrea Di Cesare, Diego Fontaneto, Sabatino Raffaella, Gianluca Corno, Sivalingam Periyasamy, Fontaneto Diego, Di Cesare Andrea, Tomasa Sbaffi, Periyasamy Sivalingam   +11 more
core   +1 more source