Results 41 to 50 of about 1,191,619 (293)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. [PDF]

, 2016
AIMS: Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins has been performed. METHODS AND
David N. Potier, Ferheen Baig, Hassan Albadawi, Javier Barallobre-Barreiro, Julianne Stoughton, Karen E. Porter, Kucukguven, Manuel Mayr, Marc Lynch, Marika Fava, Marjan Jahangiri, Metzler, Michael T. Watkins, Rahmi Oklu, Sanjay Misra, Temo Barwari, Xiaoke Yin, Xu   +17 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction

Frontiers in Cell and Developmental Biology, 2019
Craniofacial development comprises a complex process in humans in which failures or disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a common congenital anomaly that occurs due to variations in craniofacial ...
Katiúcia Batista Silva Paiva, Clara Soeiro Maas, Pâmella Monique dos Santos, José Mauro Granjeiro, José Mauro Granjeiro, Ariadne Letra, Ariadne Letra, Ariadne Letra   +7 more
doaj   +1 more source

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]

, 2017
The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Leckband, Deborah E, Underhill, Gregory H   +3 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
Recombinant growth factors are used in tissue engineering to stimulate cell proliferation, migration, and differentiation. Conventional methods of growth factor delivery for therapeutic applications employ large amounts of these bioactive cues. Effective,
Shierly W. Fok, Robert C. H. Gresham, Weston Ryan, Benjamin Osipov, Chelsea Bahney, J. Kent Leach, J. Kent Leach   +6 more
doaj   +1 more source

Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. [PDF]

, 1980
We have shown that macrophages in culture degrade the glycoproteins and amorphous elastin of insoluble extracellular matrices. Ultrastructural observation of the macrophage-matrix interaction revealed that connective tissue macromolecules were ...
Bainton, DF, Jones, PA, Werb, Z
core  

Appearance of fibronectin during the differentiation of cartilage, bone, and bone marrow. [PDF]

, 1981
Fibronectin has been localized by indirect immunofluorescence during the various phases of endochondral bone formation in response to subcutaneously implanted demineralized bone matrix.
Reddi, AH, Weiss, RE
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Higher hemoglobin levels are associated with adverse heart rate variability in a middle‐aged birth cohort

Physiological Reports
High hemoglobin (Hb) levels within normal variation range are considered beneficial. However, lower Hb levels within normal variation range are associated with healthier cardiovascular traits. Heart rate variability (HRV) and baroreflex sensitivity (BRS)
Samuli Sakko, Mikko. P. Tulppo, Peppi Koivunen, Joona Tapio   +3 more
doaj   +1 more source