Results 41 to 50 of about 1,191,682 (356)

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Extracellular regulation of metalloproteinases [PDF]

, 2015
Matrix metalloproteinases (MMPs) and adamalysin-like metalloproteinase with thrombospondin motifs (ADAMTSs) belong to the metzincin superfamily of metalloproteinases and they play key roles in extracellular matrix catabolism, activation and inactivation ...
Bannikov, Barcelona, Barmina, Barrett, Brew, Butler, Crabbe, Crabbe, Dumin, Elkins, Ellerbroek, Emonard, Emonard, Emonard, Etique, Fanjul-Fernández, Fosang, Fu, Fushimi, Galvez, Gendron, George, Geurts, Gillian Murphy, Gorovoy, Grimsley, Gu, Guo, Gálvez, Hahn-Dantona, Herz, Herz, Higashi, Iida, Kashiwagi, Kazuhiro Yamamoto, Kolkenbrock, Kowal, Kuno, Lafleur, Lillis, Linda Troeberg, Liu, Lu, Mantuano, Messaritou, Morgunova, Mu, Nagase, Nagase, Noguchi, Omura, Page-McCaw, Piccard, Quinn, Ra, Remacle, Rozanov, Sakamoto, Scilabra, Selvais, Shiomi, Sohail, Stricker, Strickland, Sudbeck, Takino, Thevenard, Troeberg, Troeberg, Uekita, Van den Steen, Van Wart, Visse, von Arnim, Walling, Wang, Weiss, Willingham, Winberg, Yamamoto, Yamamoto, Yamamoto, Yamamoto, Yang, Yu, Yáñez-Mó   +86 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

Nature Communications
Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression.
Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold, Collin Y. Ewald   +11 more
doaj   +1 more source

Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction

Frontiers in Cell and Developmental Biology, 2019
Craniofacial development comprises a complex process in humans in which failures or disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a common congenital anomaly that occurs due to variations in craniofacial ...
Katiúcia Batista Silva Paiva, Clara Soeiro Maas, Pâmella Monique dos Santos, José Mauro Granjeiro, José Mauro Granjeiro, Ariadne Letra, Ariadne Letra, Ariadne Letra   +7 more
doaj   +1 more source

Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
Recombinant growth factors are used in tissue engineering to stimulate cell proliferation, migration, and differentiation. Conventional methods of growth factor delivery for therapeutic applications employ large amounts of these bioactive cues. Effective,
Shierly W. Fok, Robert C. H. Gresham, Weston Ryan, Benjamin Osipov, Chelsea Bahney, J. Kent Leach, J. Kent Leach   +6 more
doaj   +1 more source

PU.1 controls fibroblast polarization and tissue fibrosis [PDF]

, 2019
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
Beyer, Christian, Boykin, David W., Butter, Falk, Chen, Chih-Wei, Daniel, Christoph, Dees, Clara, Distler, Jörg H. W., Distler, Oliver, Ekici, Arif, Finotto, Susetta, Gay, Steffen, Gelse, Kolja, Jüngel, Astrid, Kaplan, Mark H., Karouzakis, Emmanuel, Kiener, Hans P., Kremer, Andreas E., Kreuter, Alexander, Luber, Markus, Maier, Christiane, Matei, Alexandru-Emil, Naschberger, Elisabeth, Nutt, Stephen L., Pachera, Elena, Poon, Gregory M. K., Ramming, Andreas, Rauber, Simon, Schett, Georg, Soare, Alina, Sticherling, Michael, Stürzl, Michael, Uebe, Steffen, Weber, Stefanie, Wohlfahrt, Thomas   +33 more
core   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento, Ang, Asahi, Asahi, Barkho, Bergers, Bini, Cao, Cardone, Chinopoulos, Cunningham, Denker, Dong, Fabunmi, Fisher, Frisch, Galis, Galis, Galis, Galis, Gidday, Godin, Gross, Gu, Gu, Gurney, Haas, Haddad, Halliwell, Hamann, Harkness, Herman, Hornig, Hyslop, Itoh, Kumura, Langton, Lapchak, Larsen, Lee, Lelongt, Loftus, Lucivero, Luttun, McQuibban, Meredith, Montaner, Montaner, Nagase, Nagel, Nagy, Nagy, Nikkari, Pagenstecher, Qi, Rajagopalan, Ramos, Rekhter, Rolfe, Romanic, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sarén, Sato, Seo, Shrivastava, Shubayev, Siao, Sole, Sottrup, Sternlicht, Strongin, Sukhova, Suzuki, Suzuki, Svedin, Tsuji, Turner, Van, Vogel, Wang, Wang, Webersinke, Yepes, Ying, Zhang, Zhang, Zhang, Zhao   +91 more
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source