Results 11 to 20 of about 192,244 (159)

SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix

Molecular & Cellular Oncology, 2021
Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of ...
Jordan A. Cockfield, Zachary T. Schafer
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Exosome-mediated transduction of mechanical force regulates prostate cancer migration via microRNA

Biochemistry and Biophysics Reports, 2022
Physical cues in the extracellular microenvironment regulate cancer cell metastasis. Functional microRNA (miRNA) carried by cancer derived exosomes play a critical role in extracellular communication between cells and the extracellular microenvironment ...
Zhixiao Liu, Qishu Jin, Taofei Yan, Yinqing Wo, Huiwen Liu, Yue Wang   +5 more
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The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis

Biomimetics, 2023
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular processes, the extracellular matrix has been shown to have diverse ...
Kevin Dzobo, Collet Dandara
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Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms

Bone Research, 2023
The bone extracellular matrix (ECM) contains minerals deposited on highly crosslinked collagen fibrils and hundreds of non-collagenous proteins. Some of these proteins are key to the regulation of bone formation and regeneration via signaling pathways ...
Margalida Fontcuberta-Rigo, Miho Nakamura, Pere Puigbò   +2 more
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Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities

Journal of Oral Biology and Craniofacial Research, 2023
Salivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging, disease, and physical insult, normal remodeling of the SG microenvironment (i.e.
Milos Marinkovic, Olivia N. Tran, Hanzhou Wang, Parveez Abdul-Azees, David D. Dean, Xiao-Dong Chen, Chih-Ko Yeh   +6 more
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Intact extracellular matrix component promotes maintenance of liver-specific functions and larger aggregates formation of primary rat hepatocytes

Regenerative Therapy, 2019
The extracellular matrix (ECM) in a liver-specific extracellular matrix (L-ECM) scaffold facilitates hepatocyte viability and maintains hepatocyte functions in vitro.
Ronald P. Bual, Hiroyuki Ijima
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Decellularization Techniques for Tissue Engineering: Towards Replicating Native Extracellular Matrix Architecture in Liver Regeneration

Journal of Functional Biomaterials, 2023
The process of tissue regeneration requires the utilization of a scaffold, which serves as a structural framework facilitating cellular adhesion, proliferation, and migration within a physical environment.
Ishita Allu, Ajay Kumar Sahi, Meghana Koppadi, Shravanya Gundu, Alina Sionkowska   +4 more
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Deciphering the Relevance of Bone ECM Signaling

Cells, 2020
Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in
Natividad Alcorta-Sevillano, Iratxe Macías, Arantza Infante, Clara I. Rodríguez   +3 more
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The Repertoire of Tissue Inhibitors of Metalloproteases: Evolution, Regulation of Extracellular Matrix Proteolysis, Engineering and Therapeutic Challenges

Life, 2022
Tissue inhibitors of metalloproteases (TIMPs) belong to a fascinating protein family expressed in all Metazoa. They act as regulators of the turnover of the extracellular matrix, and they are consistently involved in essential processes.
Salvatore Costa, Maria Antonietta Ragusa, Gabriele Lo Buglio, Simone Dario Scilabra, Aldo Nicosia   +4 more
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The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes [PDF]

BioMed Research International, 2014
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton ...
Yue Gao, Shuyun Liu, Jingxiang Huang, Weimin Guo, Jifeng Chen, Li Zhang, Bin Zhao, Jiang Peng, Aiyuan Wang, Yu Wang, Wenjing Xu, Shibi Lu, Mei Yuan, Quanyi Guo   +13 more
openaire   +3 more sources