Results 41 to 50 of about 192,244 (159)

Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer [PDF]

Reproductive Biology and Endocrinology, 2004
Prostate cancer (PCa) is no exception to the multi-step process of metastasis. As PCa progresses, changes occur within the microenvironments of both the malignant cells and their targeted site of metastasis, enabling the necessary responses that result in successful translocation.
Sikes Robert A, Cooper Carlton R, Stewart Delisha A   +2 more
openaire   +3 more sources

An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix

Biology Open, 2017
Activated fibroblasts are considered major drivers of fibrotic disease progression through the production of excessive extracellular matrix (ECM) in response to signals from damaged epithelial and inflammatory cells.
Omar S. Qureshi, Hélène Bon, Breda Twomey, Gill Holdsworth, Kirsty Ford, Marianne Bergin, Linghong Huang, Mariusz Muzylak, Louise J. Healy, Vanessa Hurdowar, Timothy S. Johnson   +10 more
doaj   +1 more source

Light-Sheet Scattering Microscopy to Visualize Long-Term Interactions Between Cells and Extracellular Matrix

Frontiers in Immunology, 2022
Visualizing interactions between cells and the extracellular matrix (ECM) mesh is important to understand cell behavior and regulatory mechanisms by the extracellular environment.
Xiangda Zhou, Renping Zhao, Archana K. Yanamandra, Archana K. Yanamandra, Markus Hoth, Bin Qu, Bin Qu   +6 more
doaj   +1 more source

ColPTMScape: An open access knowledge base for tissue-specific collagen PTM maps

Matrix Biology Plus
Collagen is a key component of the extracellular matrix (ECM). In the remodeling of ECM, a remarkable variation in collagen post-translational modifications (PTMs) occurs.
Ashutosh Joshi, Ayush Nigam, Lalit Narayan Mudgal, Bhaskar Mondal, Trayambak Basak   +4 more
doaj   +1 more source

In vivo topology converts competition for cell-matrix adhesion into directional migration

Nature Communications, 2019
Migrating cells encounter multiple signals such as extracellular matrix (ECM) and chemokinetic factors but how these integrate in vivo is unclear. Here, the authors report that overall control of cell-ECM adhesion by Sema3A and Sdf1 can be converted into
Fernanda Bajanca, Nadège Gouignard, Charlotte Colle, Maddy Parsons, Roberto Mayor, Eric Theveneau   +5 more
doaj   +1 more source

Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing

Nature Communications, 2021
Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing ...
Sayan Chakraborty, Divyaleka Sampath, Melissa Ong Yu Lin, Matthew Bilton, Cheng-Kuang Huang, Mui Hoon Nai, Kizito Njah, Pierre-Alexis Goy, Cheng-Chun Wang, Ernesto Guccione, Chwee-Teck Lim, Wanjin Hong   +11 more
doaj   +1 more source

Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies

Nature Communications, 2020
The extracellular matrix (ECM) can influence tumor growth and its response to therapy. Here, the authors develop a fibrinogen and thrombin based artificial ECM that can starve tumours and prevent dissemination of cancer cells.
Di-Wei Zheng, Sheng Hong, Qiu-Ling Zhang, Xue Dong, Pei Pan, Wen-Fang Song, Wen Song, Si-Xue Cheng, Xian-Zheng Zhang   +8 more
doaj   +1 more source

Fibroblast senescence-associated extracellular matrix promotes heterogeneous lung niche

APL Bioengineering
Senescent cell accumulation in the pulmonary niche is associated with heightened susceptibility to age-related disease, tissue alterations, and ultimately a decline in lung function.
Andrew M. Howes, Nova C. Dea, Deepraj Ghosh, Krishangi Krishna, Yihong Wang, Yanxi Li, Braxton Morrison, Kimani C. Toussaint, Michelle R. Dawson   +8 more
doaj   +1 more source

Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix

International Journal of Cell Biology, 2013
Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins. Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor
Xiaodong Feng, Marcia G. Tonnesen, Shaker A. Mousa, Richard A. F. Clark   +3 more
doaj   +1 more source

Alzheimer’s Tau seeds-induced pathology enhances hippocampal extracellular diffusion

Communications Biology
The extracellular space (ECS) is a complex, dynamic network occupying about 20% of the brain, filled with a cerebrospinal fluid-like solution rich in extracellular matrix (ECM) molecules.
Juan Estaún-Panzano, Anna Lovisotto, Claire Mazzocco, Carolina Piva, Morgane Darricau, Ivo Calaresu, Quentin Gresil, Vincent Planche, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard   +11 more
doaj   +1 more source