How does the Extracellular Matrix Change in the Setting of Heart Failure?
International Journal of Medical Students, 2018 The Extracellular Matrix is a dynamic entity, showing constant degradation and deposition while providing the framework for the cardiomyocytes and interstitial proteins to lie on.
Amerikos Argyriou
doaj +1 more source
Fluorescent protein markers to tag collagenous proteins: The paradigm of procollagen VII [PDF]
, 2009 Fluorescent proteins are powerful markers allowing tracking expression, intracellular localization, and translocation of tagged proteins but their effects on the structure and assembly of complex extracellular matrix proteins has not been investigated ...
Chung, Hye J. +3 more
core +2 more sources
Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces [PDF]
arXiv, 2021 Eukaryotic cells adhere to extracellular matrix during the normal development of the organism, forming static adhesion as well as during cell motility. We study this process by considering a simplified coarse-grained model of a vesicle that has uniform adhesion energy with a flat substrate, mobile curved membrane proteins and active forces.
arxiv
Inflammation modulates expression of laminin in the central nervous system following ischemic injury
Journal of Neuroinflammation, 2012 Background Ischemic stroke induces neuronal death in the core of the infarct within a few hours and the secondary damage in the surrounding regions over a long period of time.
Ji Kyungmin, Tsirka Stella E
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Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Experimental and Molecular Medicine, 2019 Aortic aneurysm: Different locations, different causes A review of aneurysm formation, swelling in blood vessel, in the aorta, examines distinctions between two forms of the condition and the role of proteins in the extracellular matrix which surrounds ...
Sayantan Jana +3 more
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Journal of Functional Biomaterials, 2022 Substitution by artificial ovary is a promising approach to restore ovarian function, and a decellularized extracellular matrix can be used as a supporting scaffold. However, biomimetic ovary fabrication and immunogenicity requires more investigation. In
Tong Wu +4 more
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Recreation of the terminal events in physiological integrin activation. [PDF]
, 2010 Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly, and mechanotransduction.
Bobkov, Andrey A +8 more
core +3 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Convergence and positivity of finite element methods for a haptotaxis model of tumoral invasion [PDF]
arXiv, 2020 In this paper, we consider a mathematical model for the invasion of host tissue by tumour cells in a $d$-dimensional bounded domain, $d\leq 3$. This model consists of a system of differential equations describing the evolution of cancer cell density, the extracellular matrix protein density and the matrix degrading enzyme concentration.
arxiv
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q [PDF]
The Journal of Biological Chemistry 283, 44 (2008) 29888-96, 2008 Increase in vascular permeability occurs under many physiological conditions and is central in diverse human pathologies. Thrombin is a pro-coagulant serine protease, which causes the local loss of endothelial barrier integrity thereby enabling the rapid extravasation of plasma proteins and the local formation of fibrin-containing clots.
arxiv +1 more source