Proteomics Characterization of Extracellular Space Components in the Human Aorta [PDF]
, 2010 The vascular extracellular matrix (ECM) is essential for the structural integrity of the vessel wall and also serves as a substrate for the binding and retention of secreted products of vascular cells as well as molecules coming from the circulation ...
Bregant +40 more
core +2 more sources
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling. [PDF]
Nat Commun, 2020 The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Soria FN +11 more
europepmc +2 more sources
The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance
Biomolecules, 2019 The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs)
Eliska Ruzickova +4 more
doaj +1 more source
Proteome readjustments in the apoplastic space of Arabidopsis thaliana ggt1 mutant leaves exposed to UV-B radiation [PDF]
, 2015 Ultraviolet-B radiation acts as an environmental stimulus, but in high doses it has detrimental effects on plant metabolism. Plasma membranes represent a major target for ROS generated by this harmful radiation.
ARRIGONI, GIORGIO +8 more
core +2 more sources
Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form
Immuno, 2021 Peptidases generate bioactive peptides that can regulate cell signaling and mediate intercellular communication. While the processing of peptide precursors is initiated intracellularly, some modifications by peptidases may be conducted extracellularly ...
Yu Liu +3 more
doaj +1 more source
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. [PDF]
Elife, 2020 Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement.
Babola TA +3 more
europepmc +2 more sources
Promotion of Lung Cancer Metastasis by SIRT2‐Mediated Extracellular Protein Deacetylation
Advanced Science, 2023 Acetylation of extracellular proteins has been observed in many independent studies where particular attention has been given to the dynamic change of the microenvironmental protein post‐translational modifications.
Meng Wu +24 more
doaj +1 more source
eLife, 2017 Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that ...
Alex J Smith +4 more
doaj +1 more source
Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]
, 2015 GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Megalogeni, M +4 more
core +1 more source
Frontiers in Neuroscience, 2017 The relationship between extracellular space (ECS) diffusion parameters and brain drug clearance is not well-studied, especially in the context of Parkinson's disease (PD). Therefore, we used a rodent model of PD to explore the distribution and clearance
Yuan Fang +6 more
doaj +1 more source