Results 31 to 40 of about 344,575 (257)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Effective Extracellular Volume Fraction Determined by Equilibrium Contrast-Enhanced CT for Differentiating Autoimmune Pancreatitis from Pancreatic Ductal Adenocarcinoma

Diagnostics
Background/Objectives: The aim of this study was to determine whether extracellular volume (ECV) fraction as determined by contrast-enhanced computed tomography (CECT) can help distinguish between autoimmune pancreatitis (AIP) and pancreatic ductal ...
Akihiko Kanki, Yoshihiko Fukukura, Hidemitsu Sotozono, Kiyoka Maeba, Atsushi Higaki, Yuki Sato, Akira Yamamoto, Ryo Moriwake, Tsutomu Tamada   +8 more
doaj   +1 more source

Protein Dynamics in the Plant Extracellular Space

Proteomes, 2016
The extracellular space (ECS or apoplast) is the plant cell compartment external to the plasma membrane, which includes the cell walls, the intercellular space and the apoplastic fluid (APF).
Leonor Guerra-Guimarães, Carla Pinheiro, Inês Chaves, Danielle R. Barros, Cândido P. Ricardo   +4 more
doaj   +1 more source

Electrodiffusive model for astrocytic and neuronal ion concentration dynamics. [PDF]

PLoS Computational Biology, 2013
The cable equation is a proper framework for modeling electrical neural signalling that takes place at a timescale at which the ionic concentrations vary little.
Geir Halnes, Ivar Ostby, Klas H Pettersen, Stig W Omholt, Gaute T Einevoll   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Reducing Extracellular Ca2+ Induces Adenosine Release via Equilibrative Nucleoside Transporters to Provide Negative Feedback Control of Activity in the Hippocampus

Frontiers in Neural Circuits, 2017
Neural circuit activity increases the release of the purine neuromodulator adenosine into the extracellular space leading to A1 receptor activation and negative feedback via membrane hyperpolarization and inhibition of transmitter release.
Rebecca Diez, Magnus J. E. Richardson, Mark J. Wall   +2 more
doaj   +1 more source

Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

eLife, 2020
Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement.
Travis A Babola, Calvin J Kersbergen, Han Chin Wang, Dwight E Bergles   +3 more
doaj   +1 more source

Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis

ERJ Open Research, 2021
Introduction Evidence suggests that abnormalities occur in the lung microvasculature in idiopathic pulmonary fibrosis (IPF). We hypothesised that dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) could detect alterations in permeability ...
Sydney B. Montesi, Iris Y. Zhou, Lloyd L. Liang, Subba R. Digumarthy, Sarah Mercaldo, Nathaniel Mercaldo, Ravi T. Seethamraju, Bruce R. Rosen, Peter Caravan   +8 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity

Redox Biology, 2022
Hydrogen peroxide is a major redox signaling molecule underlying a novel paradigm of cell function and communication. A role for H2O2 as an intercellular signaling molecule and neuromodulator in the brain has become increasingly apparent, with evidence ...
A. Ledo, E. Fernandes, A. Salvador, J. Laranjinha, R.M. Barbosa   +4 more
doaj   +1 more source