Results 41 to 50 of about 80,278 (294)

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]

, 2013
Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Ammollo, Aziz, Borissoff, Brill, Brinkmann, Clark, Esmon, Esmon, Fuchs, Fuchs, Gladysheva, Gleber, Guthold, Komissarov, Komorowicz, Longstaff, Longstaff, Massberg, Nikolova, Rocha, Ruf, Ryan, Rábai, Rácz, Saha, Sands, Scrutton, Semeraro, Silva, Smeeth, Walker, Weisel, Weisel, Wohner, Xu, Yang, Yeromonahos   +36 more
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Neutrophil Extracellular Traps [PDF]

, 2019
Neutrophil extracellular traps (NETs) are made of a network of extracellular strings of DNA that bind pathogenic microbes. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms. Reactive oxygen species generated by the neutrophil NADPH oxidase have been shown to be essential to mediate NET ...
openaire   +2 more sources

Platelets: New bricks in the building of neutrophil extracellular traps [PDF]

, 2016
In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens through the expression of toll-like ...
Carestia, Agostina, Kaufman, Tomás, Schattner, Mirta Ana   +2 more
core   +1 more source

A Vaccine Against Group B Streptococcus: Recent Advances [PDF]

, 2020
Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally. Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and infant GBS disease and has been identified as a priority by the World ...
Carreras-Abad, C, Heath, PT, Le Doare, K, Ramkhelawon, L   +3 more
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Neutrophil Extracellular Traps: New Aspects [PDF]

Moscow University Biological Sciences Bulletin, 2020
Neutrophils are the "first line" of defense against pathogens in the locus of inflammation, where they use effector functions such as phagocytosis, degranulation, and formation of reactive oxygen species (ROS). In 2004, Artuto Zychlinsky characterized one more neutrophil effector function-the release of neutrophil extracellular traps (or NETs).
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Triptolide inhibits neutrophil extracellular trap formation [PDF]

Annals of Translational Medicine, 2021
Triptolide (PG490), as a triterpene dicyclic oxide has been reported to increase the generation of reactive oxygen species (ROS) and nitric oxide (NO) and induce apoptosis of RAW 264.7 cells in a dose-dependent manner. The activity of death NETs plays an important role in anti-bacterial processes in the human body.
Guan, Haiyu, Xie, Lifen, Ji, Zhenzhen, Song, Rui, Qi, Jieying, Nie, Xiaoli   +5 more
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Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. [PDF]

, 2014
Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus ...
Butcher, Brad, Carlson, Adam Q, Graf, Jonathan, Imboden, John B, Jen, Kuang-Yu, Sam, Ramin, Tuot, Delphine S   +6 more
core   +2 more sources

Neutrophil extracellular traps in sheep mastitis [PDF]

Veterinary Research, 2015
Neutrophil extracellular traps (NETs) are structures composed of DNA, histones, and antimicrobial proteins that are released extracellularly by neutrophils and other immune cells as a means for trapping and killing invading pathogens. Here, we describe NET formation in milk and in mammary alveoli of mastitic sheep, and provide a dataset of proteins ...
Pisanu S., Cubeddu T., Pagnozzi D., Rocca S., Cacciotto C., Alberti A., Marogna G., Uzzau S., Addis M. F.   +8 more
openaire   +3 more sources

Neutrophil Extracellular Traps Orchestrate Necroinflammation [PDF]

Journal of the American Society of Nephrology, 2017
In 1869, a young Swiss student who was interested in the study of the nuclei of cells succeeded in separating the nuclei from the cytoplasm of white blood cell from pus, which he obtained from discarded surgical bandages from the local surgical clinic.[1][1] He found that the nuclei were made of ...
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Neutrophil Extracellular Traps Initiate Gallstone Formation [PDF]

Immunity, 2019
The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones.
Luis E. Muñoz, Sebastian Boeltz, Rostyslav Bilyy, Christine Schauer, Aparna Mahajan, Navena Widulin, Anika Grüneboom, Irmgard Herrmann, Edgyda Boada, Manfred Rauh, Veit Krenn, Mona H.C. Biermann, Malgorzata J. Podolska, Jonas Hahn, Jasmin Knopf, Christian Maueröder, Solomiya Paryzhak, Tetiana Dumych, Yi Zhao, Markus F. Neurath, Markus H. Hoffmann, Tobias A. Fuchs, Moritz Leppkes, Georg Schett, Martin Herrmann   +24 more
openaire   +3 more sources