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Journal of Extracellular Biology, 2022 Extracellular vesicle (EV) research has grown rapidly in recent years, largely due to the potential use of EVs as liquid biopsy biomarkers or therapeutics.
Colin L. Hisey +8 more
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Coarse-Grained Molecular Simulation of Extracellular Vesicles Squeezing for Drug Loading [PDF]
https://pubs.rsc.org/en/content/articlelanding/2023/cp/d3cp00387f, 2022 In recent years, extracellular vesicles such have become promising carriers as the next-generation drug delivery platforms. Effective loading of exogenous cargos without compromising the extracellular vesicle membrane is a major challenge. Rapid squeezing through nanofluidic channels is a widely used approach to load exogenous cargoes into the EV ...
arxiv +1 more source
Center-Periphery Structure in Communities: Extracellular Vesicles [PDF]
Quantitative Science Studies (2022), 2021 Clustering and community detection in networks are of broad interest and have been the subject of extensive research that spans several fields. We are interested in the relatively narrow question of detecting communities of scientific publications that are linked by citations. These publication communities can be used to identify scientists with shared
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Multiscale Dynamics of Lipid Vesicles in Polymeric Microenvironment [PDF]
Membranes 2022, 12(7), 640, 2022 Understanding dynamic and complex interaction of biological membranes with extracellular matrices plays a crucial role in controlling a variety of cell behavior and functions, from cell adhesion and growth to signaling and differentiation. Tremendous interest in tissue engineering has made it possible to design polymeric scaffolds mimicking the ...
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Machine Learning Characterization of Cancer Patients-Derived Extracellular Vesicles using Vibrational Spectroscopies [PDF]
Applied Intelligence (2022), 2021 The early detection of cancer is a challenging problem in medicine. The blood sera of cancer patients are enriched with heterogeneous secretory lipid bound extracellular vesicles (EVs), which present a complex repertoire of information and biomarkers, representing their cell of origin, that are being currently studied in the field of liquid biopsy and ...
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Machine Intelligence-Driven Classification of Cancer Patients-Derived Extracellular Vesicles using Fluorescence Correlation Spectroscopy: Results from a Pilot Study [PDF]
Neural Computing and Applications (2023), 2022 Patient-derived extracellular vesicles (EVs) that contains a complex biological cargo is a valuable source of liquid biopsy diagnostics to aid in early detection, cancer screening, and precision nanotherapeutics. In this study, we predicted that coupling cancer patient blood-derived EVs to time-resolved spectroscopy and artificial intelligence (AI ...
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Towards rapid extracellular vesicles colorimetric detection using optofluidics-enhanced color-changing optical metasurface [PDF]
, 2023 Efficient transportation and delivery of analytes to the surface of optical sensors are crucial for overcoming limitations in diffusion-limited transport and analyte sensing. In this study, we propose a novel approach that combines metasurface optics with optofluidics-enabled active transport of extracellular vesicles (EVs).
arxiv +1 more source
Quality of approximating a mass-emitting object by a point source in a diffusion model [PDF]
, 2023 For the sake of computational efficiency and for theoretical purposes, in mathematical modelling, the Dirac Delta distributions are often utilized as a replacement for cells or vesicles, since the size of cells or vesicles is much smaller than the size of the surrounding tissues.
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AOC; Assembling Overlapping Communities [PDF]
Quantitative Science Studies (2022), 2022 Through discovery of meso-scale structures, community detection methods contribute to the understanding of complex networks. Many community finding methods, however, rely on disjoint clustering techniques, in which node membership is restricted to one community or cluster.
arxiv +1 more source
Scalable trapping of single nanosized extracellular vesicles using plasmonics [PDF]
, 2023 Heterogeneous nanoscale particles released by cells known as extracellular vesicles (EVs) are actively investigated for early disease detection1, monitoring2, and advanced therapeutics3. Due to their extremely small size, the stable trapping of nano-sized EVs using diffraction-limited optical tweezers4 has been met with challenges.
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