Results 131 to 140 of about 26,166 (275)
Journal of Physiology, 2019 We present a novel protocol to quantify extrasynaptic NMDA receptor function utilizing the semi‐selective activation of extrasynaptic receptors by ambient extracellular glutamate in acute brain slices from adult rats.
Alexander Moldavski +3 more
semanticscholar +1 more source
MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
wiley +1 more source
Frontiers in Physiology, 2012 Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2 ...
Olga eKopach +3 more
doaj +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.ABSTRACT Aging is a complex process that frequently includes cognitive decline with memory loss. In the hippocampus, the number of somatostatin‐positive (Sst+) GABAergic interneurons in the hilar region of the dentate gyrus decreases with age. We previously showed that selective ablation of Sst+ dentate hilar interneurons is sufficient to induce ...
Rajasekar Nagarajan +5 more
wiley +1 more source
Frontiers in Physiology, 2012 Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic ...
Olivier eCamiré +2 more
doaj +1 more source
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes [PDF]
, 2015 BACKGROUND: GABAA receptor subunit composition has a profound effect on the receptor's physiological and pharmacological properties. The receptor β subunit is widely recognised for its importance in receptor assembly, trafficking and post-translational ...
Smart, TG, Villumsen, IS, Wellendorph, P
core +1 more source
Extrasynaptic δ‐GABAA receptors are high‐affinity muscimol receptors
Journal of Neurochemistry, 2019 Muscimol, the major psychoactive ingredient in the mushroom Amanita muscaria, has been regarded as a universal non‐selective GABA‐site agonist. Deletion of the GABAA receptor (GABAAR) δ subunit in mice (δKO) leads to a drastic reduction in high‐affinity ...
Ali Y Benkherouf +7 more
semanticscholar +1 more source
Tremor and Other Hyperkinetic Movements, 2018 Background Metabolic imaging has revealed excessive cerebellar activity in essential tremor patients. Golgi cells control cerebellar activity by releasing gamma-aminobutyric acid (GABA) onto synaptic and extrasynaptic receptors on cerebellar granule ...
A. Handforth +3 more
semanticscholar +1 more source
When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]
, 2016 Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core +1 more source
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content
Cell Reports, 2019 Summary: In mature neurons, postsynaptic N-methyl-D-aspartate receptors (NMDARs) are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are connected
Andrew M. Chiu +6 more
doaj +1 more source