Results 61 to 70 of about 57,690 (307)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Extremal problems related to convexity

Journal of Inequalities and Applications, 2016
We consider the extremal problem of maximizing functions u in the class of real-valued biconvex functions satisfying a boundary condition ψ on a product of the unit ball with itself, with the ℓ p $\ell^{p}$ -norm. In 1986, Burkholder explicitly found the
Aimo Hinkkanen, Sineenuch Suwannaphichat
doaj   +1 more source

Flows of rotating extremal attractor black holes

Journal of High Energy Physics, 2023
We investigate the attractor mechanism of five-dimensional extremal rotating black holes in Einstein gravity minimally coupled with a multiplet complex scalar.
Norihiro Iizuka, Akihiro Ishibashi, Kengo Maeda   +2 more
doaj   +1 more source

Some qualitative properties of solutions to a nonlinear fractional differential equation involving two Φ-Caputo fractional derivatives

AIMS Mathematics, 2022
The momentous objective of this work is to discuss some qualitative properties of solutions such as the estimate of the solutions, the continuous dependence of the solutions on initial conditions and the existence and uniqueness of extremal solutions to ...
Choukri Derbazi , Qasem M. Al-Mdallal, Fahd Jarad, Zidane Baitiche   +3 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Infinity Laplace equation with non-trivial right-hand side

Electronic Journal of Differential Equations, 2010
We analyze the set of continuous viscosity solutions of the infinity Laplace equation $-Delta^N_{infty}w(x) = f(x)$, with generally sign-changing right-hand side in a bounded domain.
Guozhen Lu, Peiyong Wang
doaj  

Sequences of extremal radially excited rotating black holes

, 2013
In Einstein-Maxwell-Chern-Simons theory the extremal Reissner-Nordstr\"om solution is no longer the single extremal solution with vanishing angular momentum, when the Chern-Simons coupling constant reaches a critical value.
Blazquez-Salcedo, Jose Luis, Kunz, Jutta, Navarro-Lerida, Francisco, Radu, Eugen   +3 more
core   +1 more source

String theory extensions of Einstein-Maxwell fields: the static case [PDF]

, 2002
We present a new approach for generation of solutions in the four-dimensional heterotic string theory with one vector field and in the five-dimensional bosonic string theory starting from the static Einstein-Maxwell fields.
ALFREDO HERRERA-AGUILAR, Galtsov D. V., Galtsov D. V., Herrera-Aguilar A., Kechkin O. V., Mazur P. O., OLEG V. KECHKIN, Rogatko M.   +7 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source