Results 91 to 100 of about 27,592 (211)

Species Differences in Ezetimibe Glucuronidation

Metabolites
Background: Peclinical and clinical studies have revealed that ezetimibe, an approved cholesterol-absorption inhibitor, is rapidly and extensively metabolized to a more potent metabolite, ezetimibe glucuronide.
Shalom Emmanuel, Eric A. Asare, Ting Du, Huan Xie, Dong Liang, Song Gao   +5 more
doaj   +1 more source

Comparison of different strategies to measure medication adherence via claims data in patients with chronic heart failure [PDF]

, 2019
Medication adherence correlates with morbidity and mortality in patients with chronic heart failure (CHF), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of ...
Griese‐Mammen, Nina, Ihle, Peter, Krueger, Katrin, Laufs, Ulrich, Parrau, Natalie, Schubert, Ingrid, Schulz, Martin   +6 more
core   +1 more source

Comparison of cardiovascular outcomes between once‐weekly semaglutide and dulaglutide in adults with type 2 diabetes and established atherosclerotic cardiovascular disease in the United States

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2661-2671, April 2026.
Abstract Aims This study aims to compare the risk of major adverse cardiovascular events (MACE) among United States individuals with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD) treated with once‐weekly semaglutide vs. dulaglutide.
Xi Tan, Yuanjie Liang, Lin Xie, Joanna Harton, Cynthia Gutierrez, Chalak Muhammad, Caroline Swift, Adam de Havenon   +7 more
wiley   +1 more source

Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease [PDF]

, 2014
Background Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein.
Abecasis, Goncalo, Altshuler, David, Ardissino, Diego, Asselta, Rosanna, Assimes, Themistocles L., Auer, Paul, Austin, Erin, Ballantyne, Christie, Bastarache, Lisa A., Boerwinkle, Eric, Buring, Julie E., Chasman, Daniel I., Cresci, Sharon, Crosby, Jacy, Danesh, John, Deloukas, Panos, Denny, Joshua C., Do, Ron, Duga, Stefano, Elosua, Roberto, Erdmann, Jeanette, Farrall, Martin, Ferrario, Paola, Fontanillas, Pierre, Gabriel, Stacey, Gibbs, Richard A., Goel, Anuj, Gupta, Namrata, Hazen, Stanley L., Hovingh, G. Kees, Jackson, Rebecca, Kastrati, Adnan, Kathiresan, Sekar, Kessler, Thorsten, Kullo, Iftikhar J., König, Inke, Lander, Eric S., Lange, Leslie A., Laugwitz, Karl-Ludwig, Lin, Dan-Yu, Marrugat, Jaume, Marziliano, Nicola, McPherson, Ruth, Meitinger, Thomas, Merlini, Piera A., Morrison, Alanna C., Muzny, Donna, Natarajan, Pradeep, Nickerson, Deborah A., Notarangelo, Maria Francesca, O'Donnell, Christopher J., Palmer, Colin, Peloso, Gina M., Rader, Daniel J., Reilly, Muredach, Reiner, Alex P., Rich, Stephen S., Ridker, Paul M., Roden, Dan M., Rotter, Jerome I., Saleheen, Danish, Schick, Ursula, Schunkert, Heribert, Schwartz, Stephen M., Shaffer, Christian M., Siscovick, David, Spertus, John, Stitziel, Nathan O., Sunyaev, Shamil, Tang, Zheng-zheng, Tracy, Russell, Watkins, Hugh, Weeke, Peter E., Wilensky, Robert, Wilson, James G., Won, Hong-Hee, Ye, Zi   +76 more
core   +2 more sources

Elevated triglyceride‐glucose index is associated with increased risk of chronic kidney disease and end‐stage renal disease in type 1 diabetes: Nationwide cohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2784-2794, April 2026.
Abstract Aims Prognostic markers for microvascular complications in type 1 diabetes are needed because factors beyond hyperglycaemia contribute to this risk. The triglyceride‐glucose (TyG) index is an established marker of vascular complications in type 2 diabetes; however, its clinical significance in type 1 diabetes remains unknown.
Rosa Oh, Seohyun Kim, So Hyun Cho, Ji Yoon Kim, Myunghwa Jang, Sang Ho Park, You‐Bin Lee, Sang‐Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim   +10 more
wiley   +1 more source

Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]

, 2017
No abstract ...
Packard, Chris J.
core   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2582-2593, April 2026.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes

Journal of Lipid Research, 2012
Enterocyte cholesterol homeostasis reflects aggregated rates of sterol synthesis, efflux, and uptake from plasma and gut lumen. Cholesterol synthesis and LDL uptake are coordinately regulated by sterol regulatory element-binding proteins (SREBP), whereas
Luke J. Engelking, Matthew R. McFarlane, Christina K. Li, Guosheng Liang   +3 more
doaj   +1 more source

How to treat hypercholesterolaemia [PDF]

, 2008
An elevated low density lipoprotein cholesterol is a major cause of atherosclerosis. Reducing the concentration of this lipoprotein stabilises atherosclerotic plaques, and may lead to regression of the atherosclerosis.
Colquhoun, D.
core   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, Volume 293, Issue 7, Page 2009-2021, April 2026.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source