Results 81 to 90 of about 672,429 (301)

Phosphatidylinositol 3-kinase-associated protein (PI3KAP)/XB130 crosslinks actin filaments through its actin binding and multimerization properties in vitro and enhances endocytosis in HEK293 cells.

Frontiers in Endocrinology, 2016
Actin-crosslinking proteins control actin filament networks and bundles and contribute to various cellular functions including regulation of cell migration, cell morphology and endocytosis.
Daisuke Yamanaka, Daisuke Yamanaka, Daisuke Yamanaka, Takeshi Akama, Kazuhiro Chida, Shiro Minami, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi   +8 more
doaj   +1 more source

Structure of the Lifeact–F-actin complex

PLOS Biology, 2020
Abstract Lifeact is a short actin-binding peptide that is used to visualize filamentous actin (F-actin) structures in live eukaryotic cells using fluorescence microscopy. However, this popular probe has been shown to alter cellular morphology by affecting the structure of the cytoskeleton. The molecular basis for such
Belyy, Alexander, Merino, Felipe, Sitsel, Oleg, Raunser, Stefan   +3 more
openaire   +6 more sources

Microrheology probes length scale dependent rheology [PDF]

, 2006
We exploit the power of microrheology to measure the viscoelasticity of entangled F-actin solutions at different length scales from 1 to 100 mu m over a wide frequency range.
A. R. Bausch, B. D. Hoffman, D. A. Weitz, E. Frey, J. C. Crocker, J. Liu, K. Kroy, K. Kroy, M. L. Gardel, P. A. Janmey   +9 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

F-actin architecture determines the conversion of chemical energy into mechanical work

Nature Communications
Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell division to migration. A fundamental driver of cellular mechanical work is the actin cytoskeleton, composed of filamentous actin (F-actin) and myosin motors, where
Ryota Sakamoto, Michael P. Murrell
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Nuclear Herpesvirus Capsid Motility Is Not Dependent on F-Actin

mBio, 2014
A considerable part of the herpesvirus life cycle takes place in the host nucleus. While much progress has been made to understand the molecular processes required for virus replication in the nucleus, much less is known about the temporal and spatial ...
Jens B. Bosse, Stina Virding, Stephan Y. Thiberge, Julian Scherer, Harald Wodrich, Zsolt Ruzsics, Ulrich H. Koszinowski, Lynn W. Enquist   +7 more
doaj   +1 more source

Regulation of pancreatic β-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway

, 2006
We have previously isolated two MIN6 beta-cell sublines, B1, highly responsive to glucose-stimulated insulin secretion, and C3, markedly refractory (Lilla, V., Webb, G., Rickenbach, K., Maturana, A., Steiner, D. F., Halban, P. A. and Irminger, J.
Halban, PA, Min, L, Pessin, JE, Tomas, A, Yermen, B   +4 more
core   +2 more sources

Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling [PDF]

, 2006
We used confocal microscopy and in vitro analyses to show that Nicotiana tabacum WLIM1, a LIM domain protein related to animal Cys-rich proteins, is a novel actin binding protein in plants.
Thomas, Clément, Hoffmann, Céline, Dieterle, Monika, Van Troys, Marleen, Ampe, Christophe, Steinmetz, André   +5 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source