Results 61 to 70 of about 672,429 (301)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

F- and G-actin concentrations in lamellipodia of moving cells.

PLoS ONE, 2009
Cells protrude by polymerizing monomeric (G) into polymeric (F) actin at the tip of the lamellipodium. Actin filaments are depolymerized towards the rear of the lamellipodium in a treadmilling process, thereby supplementing a G-actin pool for a new round
Stefan A Koestler, Klemens Rottner, Frank Lai, Jennifer Block, Marlene Vinzenz, J Victor Small   +5 more
doaj   +1 more source

Cingulin interacts with F‐actin in vitro [PDF]

FEBS Letters, 2001
Cingulin, a M r 140–160 kDa protein of the cytoplasmic plaque of epithelial tight junctions (TJ), interacts in vitro with TJ proteins and myosin. Here we investigated cingulin interaction with actin, using His‐tagged, full‐length Xenopus laevis cingulin expressed in insect cells, and glutathione S‐transferase (GST) fusion proteins of fragments of ...
D'atri, Fabio, Citi, Sandra
openaire   +5 more sources

Polymer Induced Bundling of F-actin and the Depletion Force

, 2004
The inert polymer polyethylene glycol (PEG) induces a "bundling" phenomenon in F-actin solutions when its concentration exceeds a critical onset value C_o.
A. A. Louis, A. L. Barabasi, A. Suzuki, B. H. Zimm, B. Sharp, D. Chandler, E. J. W. Verwey, F. Gittes, F. Oosawa, H. Isambert, H. J. Kinosian, J. G. Dewey, J. N. Israelachvili, J. Ray, J. Spudich, J. X. Tang, J. X. Tang, K. Devanand, L. Schafer, M. Carlier, P. deGennes, P. Sheterline, S. Asakura, W. H. Press, X. Yu   +24 more
core   +1 more source

The F-actin filament capping protein CapG is a bona fide nucleolar protein [PDF]

, 2008
Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus ...
Gettemans, Jan, Hubert, Thomas, Van Impe, Katrien, Vandekerckhove, Joël   +3 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Passive and active microrheology for cross-linked F-actin networks in vitro [PDF]

, 2009
Actin filament (F-actin) is one of the dominant structural constituents in the cytoskeleton. Orchestrated by various actin-binding proteins (ABPs), F-actin is assembled into higher-order structures such as bundles and networks that provide mechanical ...
Ferrer, Jorge M, Kamm, Roger Dale, Lang, Matthew J, Lee, Hyungsuk, Nakamura, Fumihiko   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Tetrahymena Elongation Factor-1α Binds to Hsp70 Family Proteins [PDF]

, 1999
Translation elongation factor 1α (EF-1α) catalyzes the GTP-dependent binding of aminoacyl-tRNA to the ribosome. We previously reported that Tetrahymena EF-1α induced bundles of rabbit skeletalmuscle F-actin as well as Tetrahymena F-actin (Kurasawa et al.,
Kurasawa Yasuhiro, Numata Osamu, Watanabe Yoshio, 沼田 治   +3 more
core   +1 more source