Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation [PDF]
Cell Reports, 2015 F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood.
Charlotte F. Kelley +12 more
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Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport [PDF]
Nature Communications, 2019 PACSIN proteins are known to mediate membrane tubulation. Here the authors show that PACSIN - positive membranous tubules extend from the ciliary pocket membrane and during ciliogenesis from the ciliary vesicle to the plasma membrane, called ...
Christine Insinna +10 more
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Publisher Correction: Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport [PDF]
Nature Communications, 2019 In the original version of this Article, the fifth sentence of the abstract incorrectly read ‘Remarkably, we show that PACSIN1 and EHD1 assemble membrane t7ubules from the developing intracellular cilium that attach to the plasma membrane, creating an ...
Christine Insinna +10 more
doaj +5 more sources
The F-BAR Domain of Rga7 Relies on a Cooperative Mechanism of Membrane Binding with a Partner Protein during Fission Yeast Cytokinesis [PDF]
Cell Reports, 2019 Summary: F-BAR proteins bind the plasma membrane (PM) to scaffold and organize the actin cytoskeleton. To understand how F-BAR proteins achieve their PM association, we studied the localization of a Schizosaccharomyces pombe F-BAR protein Rga7, which ...
Yajun Liu +4 more
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F-BAR domain proteins: Families and function. [PDF]
Commun Integr Biol, 2010 The F-BAR domain is emerging as an important player in membrane remodeling pathways. F-BAR domain proteins couple membrane remodeling with actin dynamics associated with endocytic pathways and filopodium formation. Here, we provide a comprehensive analysis of F-BAR domain proteins in terms of their evolutionary relationships and protein function. F-BAR
Ahmed S +4 more
europepmc +4 more sources
Membrane sculpting by F-BAR domains studied by molecular dynamics simulations. [PDF]
PLoS Computational Biology, 2013 Interplay between cellular membranes and their peripheral proteins drives many processes in eukaryotic cells. Proteins of the Bin/Amphiphysin/Rvs (BAR) domain family, in particular, play a role in cellular morphogenesis, for example curving planar ...
Hang Yu, Klaus Schulten
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Small GTPase Cdc42, WASP, and scaffold proteins for higher-order assembly of the F-BAR domain protein. [PDF]
Sci Adv, 2023 The higher-order assembly of Bin-amphiphysin-Rvs (BAR) domain proteins, including the FCH-BAR (F-BAR) domain proteins, into lattice on the membrane is essential for the formation of subcellular structures. However, the regulation of their ordered assembly has not been elucidated.
Wan Mohamad Noor WNI +8 more
europepmc +3 more sources
Coordinated autoinhibition of F-BAR domain membrane binding and WASp activation by Nervous Wreck. [PDF]
Proc Natl Acad Sci U S A, 2016 SignificanceMembrane-deforming proteins cooperate with the cytoskeleton to sculpt lipid bilayers into complex and dynamic geometries, but we still do not understand how their activities are temporally and spatially regulated in cells. Here we show that the neuronal membrane remodeling protein Nervous Wreck (Nwk) is autoinhibited by intramolecular ...
Stanishneva-Konovalova TB +6 more
europepmc +4 more sources
FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. [PDF]
Blood, 2015 Key PointsThe F-BAR protein PACSIN2 associates with the initiating demarcation membrane system in megakaryocytes. FlnA binding to the PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes, platelets, and in vitro.
Begonja AJ +13 more
europepmc +4 more sources
The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions [PDF]
Nature Communications, 2016 Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens ...
Yvonne L. Dorland +13 more
doaj +2 more sources