Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation [PDF]
Cell Reports, 2015 F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood.
Charlotte F. Kelley +12 more
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Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport [PDF]
Nature Communications, 2019 PACSIN proteins are known to mediate membrane tubulation. Here the authors show that PACSIN - positive membranous tubules extend from the ciliary pocket membrane and during ciliogenesis from the ciliary vesicle to the plasma membrane, called ...
Christine Insinna +10 more
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Publisher Correction: Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport [PDF]
Nature Communications, 2019 In the original version of this Article, the fifth sentence of the abstract incorrectly read ‘Remarkably, we show that PACSIN1 and EHD1 assemble membrane t7ubules from the developing intracellular cilium that attach to the plasma membrane, creating an ...
Christine Insinna +10 more
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The F-BAR Domain of Rga7 Relies on a Cooperative Mechanism of Membrane Binding with a Partner Protein during Fission Yeast Cytokinesis [PDF]
Cell Reports, 2019 Summary: F-BAR proteins bind the plasma membrane (PM) to scaffold and organize the actin cytoskeleton. To understand how F-BAR proteins achieve their PM association, we studied the localization of a Schizosaccharomyces pombe F-BAR protein Rga7, which ...
Yajun Liu +4 more
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Membrane sculpting by F-BAR domains studied by molecular dynamics simulations. [PDF]
PLoS Computational Biology, 2013 Interplay between cellular membranes and their peripheral proteins drives many processes in eukaryotic cells. Proteins of the Bin/Amphiphysin/Rvs (BAR) domain family, in particular, play a role in cellular morphogenesis, for example curving planar ...
Hang Yu, Klaus Schulten
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The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions [PDF]
Nature Communications, 2016 Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens ...
Yvonne L. Dorland +13 more
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A proof of strong normalisation using domain theory [PDF]
Logical Methods in Computer Science, 2007 Ulrich Berger presented a powerful proof of strong normalisation using domains, in particular it simplifies significantly Tait's proof of strong normalisation of Spector's bar recursion.
Thierry Coquand, Arnaud Spiwack
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Strong normalisation for applied lambda calculi [PDF]
Logical Methods in Computer Science, 2005 We consider the untyped lambda calculus with constructors and recursively defined constants. We construct a domain-theoretic model such that any term not denoting bottom is strongly normalising provided all its `stratified approximations' are.
Ulrich Berger
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Phase separation drives cortical enrichment of the F-BAR proteins Rga7 and Rga8 to maintain cell integrity [PDF]
Cellular and Molecular Life SciencesPolarized cell growth necessitates the dynamic remodeling of the plasma membrane, a process requiring BAR domain-containing proteins. While classical BAR proteins, with their crescent-shaped structure, are well characterized, the mechanisms underlying ...
Biyu Zheng +11 more
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The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. [PDF]
PLoS ONE, 2013 The inverse F-BAR (IF-BAR) domain proteins srGAP1, srGAP2 and srGAP3 are implicated in neuronal development and may be linked to mental retardation, schizophrenia and seizure.
Yue Ma +5 more
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