Results 61 to 70 of about 1,113,401 (243)
G3: Genes, Genomes, Genetics, 2019 In a large-scale RNAi screen in Tribolium castaneum for genes with knock-down phenotypes in the larval somatic musculature, one recurring phenotype was the appearance of larval muscle fibers that were significantly thinner than those in control animals ...
Dorothea Schultheis +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Loss of cell–cell adhesions is the indispensable first step for cancer cells to depart from the primary tumor mass to metastasize. Metastasis suppressor 1 (MTSS1) is frequently lost in metastatic tissues, correlating to advanced tumor stages and poor ...
Shixing Zheng +10 more
doaj +1 more source
The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis [PDF]
Cell, 2009 During brain development, proper neuronal migration and morphogenesis is critical for the establishment of functional neural circuits. Here we report that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those ...
Guerrier, Sabrice +8 more
openaire +2 more sources
HeliyonIntracellular membrane tubules play a crucial role in diverse cellular processes, and their regulation is facilitated by Bin-Amphiphysin-Rvs (BAR) domain-containing proteins.
Bhagaban Mallik +5 more
doaj +1 more source
On the relative asymptotic expressivity of inference frameworks [PDF]
Logical Methods in Computer ScienceWe consider logics with truth values in the unit interval $[0,1]$. Such logics are used to define queries and to define probability distributions.
Vera Koponen, Felix Weitkämper
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Nonhomogeneous nonlinear integral equations on bounded domains
AIMS Mathematics, 2023 This paper investigates the existence of positive solutions for a nonhomogeneous nonlinear integral equation of the form $ \begin{equation} u^{p-1}(x) = \int_{\Omega} \frac{u(y)}{|x-y|^{n-\alpha}} d y+\int_{\Omega} \frac{f(y)}{|x-y|^{n-\alpha}} d y, \
Xing Yi
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Extreme(ly) mean(ingful): Sequential formation of a quality group
, 2010 The present paper studies the limiting behavior of the average score of a sequentially selected group of items or individuals, the underlying distribution of which, $F$, belongs to the Gumbel domain of attraction of extreme value distributions.
Krieger, Abba M. +2 more
core +1 more source
Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles [PDF]
Journal of Cell Science, 2008 PCH family proteins are fundamentally important proteins, linking membrane curvature events with cytoskeletal reorganisation. One group, the MEGAPs (also called srGAPs and WRPs) contain RhoGAP domains in addition to the F-BAR domain. We disrupted MEGAP1 and MEGAP2 in Dictyostelium both singly and in combination. We found a strong cytoskeletal phenotype
Robert J W, Heath, Robert H, Insall
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source