Results 101 to 110 of about 1,061 (120)

Association of FHR5 With Disease Severity in ANCA-Associated Vasculitis. [PDF]

Kidney Int Rep
Li YJ, Chen SF, Li ZY, Zhu L, Wang SX, Zhao MH, Little MA, Chen M.   +7 more
europepmc   +1 more source

Functional Properties of Complement Factor H-Related Proteins FHR-3 and FHR-4: Binding to the C3d Region of C3b and Differential Regulation by Heparin [PDF]

FEBS Letters, 1999
The human factor H‐related proteins FHR‐3 and FHR‐4 are members of a family of proteins related to the complement factor H. Here, we report that the two proteins bind to the C3d region of complement C3b. The apparent K A values for the interactions of FHR‐3 and FHR‐4 with C3b are 7.5×106 M−1 and 2.9×106 M−1, respectively. Binding studies performed with
Seppo Meri, Peter F Zipfel, Outi Vaarala
exaly   +3 more sources

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Biochemical and Functional Characterization of the Factor-H-Related Protein 4 (FHR-4)

Immunopharmacology, 1997
Factor-H-related proteins and the complement regulatory protein factor H represent a family of structurally and immunologically related plasma proteins. The function of the various factor-H-related proteins are currently unclear and under investigation.
Peter F Zipfel, Christine Skerka, Jens Hellwage   +2 more
exaly   +3 more sources

Human Factor H-Related Protein 5 (FHR-5): A New Complement-Associated Protein

Journal of Biological Chemistry, 2001
A novel human plasma protein has been identified as a universal component of complement deposits, when complement is detected immunohistochemically in vivo. The protein is homologous to complement factor H and related proteins and has been designated factor H-related protein 5 (FHR-5).
Bruce E Kemp, Peter Cowan, David A Power
exaly   +2 more sources

The Human Factor H-Related Protein 4 (FHR-4): A Novel Short Consensus Repeat-Containing Protein Is Associated With Human Triglyceride-Rich Lipoproteins

Journal of Biological Chemistry, 1997
A novel apoprotein of an apparent molecular mass of 86 kDa in its unreduced form was identified in human triglyceride-rich lipoproteins. This protein was purified and the amino acid sequence of six proteolytic fragments was found to overlap with that of the factor H-related proteins. In parallel we identified the cDNA encoding a new complement factor H-
Peter F Zipfel, Christine Skerka, Jens Hellwage   +2 more
exaly   +2 more sources

Factor H-related protein 3 (FHR-3) deposition in kidney allografts – localization and correlation with complement activation

2023
Abstract Introduction Factor H-related proteins (FHRs) have emerged as novel players in complement-mediated diseases, as they exhibit structural resemblances to factor H but lack the regulatory domains, enabling them to antagonize factor H and increase complement activation through several activities.
Felix Poppelaars, Nicole Schäfer, Anita H. Meter-Arkema, Shrey Purohit, Bernardo Faria, Mariana Gaya da Costa, V. Michael Holers, Mohamed R. Daha, Diana Pauly, Marc A. Seelen, Joshua M. Thurman   +10 more
openaire   +1 more source

Interaction of factor H-related proteins FHR-3 and FHR-4 with the third component of complement

Molecular Immunology, 1998
J. Hellwage, T.S. Jokiranta, V. Koistinen, S. Meri, P.F. Zipfel   +4 more
openaire   +1 more source

Functional comparison of human factor H-related protein 4 (FHR-4) isoforms

Molecular Immunology, 2007
Michael Mihlan, Peter F. Zipfel, Mihály Józsi   +2 more
openaire   +1 more source

Factor H-related protein 4 (FHR-4) interacts with C-reactive protein in vitro and in vivo

Molecular Immunology, 2007
Michael Mihlan, Markus Huber-Lang, Peter F. Zipfel, Mihály Józsi   +3 more
openaire   +1 more source

Binding of the human Factor H-related protein (FHR-1) to Borrelia burgdorferi is mediated by complement regulator-acquiring surface proteins

Molecular Immunology, 2007
Katrin Haupt, Reinhard Wallich, Peter Kraiczy, Volker Brade, Christine Skerka, Peter F. Zipfel   +5 more
openaire   +1 more source