Results 41 to 50 of about 1,061 (120)

Complement Activation by Post‐Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek, Leendert A. Trouw   +1 more
wiley   +1 more source

Functional Characterization of Secreted Aspartyl Proteases in Candida parapsilosis

mSphere, 2019
Candida parapsilosis is an emerging non-albicans Candida species that largely affects low-birth-weight infants and immunocompromised patients. Fungal pathogenesis is promoted by the dynamic expression of diverse virulence factors, with secreted ...
Dhirendra Kumar Singh, Tibor Németh, Alexandra Papp, Renáta Tóth, Szilvia Lukácsi, Olga Heidingsfeld, Jiri Dostal, Csaba Vágvölgyi, Zsuzsa Bajtay, Mihály Józsi, Attila Gácser   +10 more
doaj   +1 more source

The human factor H protein family – an update

Frontiers in Immunology
Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor, Noémi Sándor, Andrea E. Schneider, Alexandra T. Matola, Veronika H. Barbai, Dániel Bencze, Hani Hashim Hammad, Alexandra Papp, Dorottya Kövesdi, Dorottya Kövesdi, Barbara Uzonyi, Barbara Uzonyi, Mihály Józsi, Mihály Józsi   +13 more
doaj   +1 more source

Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats

Experimental Physiology, Volume 111, Issue 8, Page 3667-3683, 1 August 2026.
Abstract Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogramming window, evaluating the long‐term effects of CSE supplementation during this period. MUN and control
Santiago Ruvira, Pilar Rodríguez‐Rodríguez, Metee Iampanichakul, Begoña Quintana‐Villamandos, Dolores Morales, David Ramiro‐Cortijo, Silvia M. Arribas   +6 more
wiley   +1 more source

Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression

Nature Communications
Dysregulation of the alternative pathway (AP) of the complement system is a significant contributor to age-related macular degeneration (AMD), a primary cause of irreversible vision loss worldwide.
M. A. Zouache, B. T. Richards, C. M. Pappas, R. A. Anstadt, J. Liu, T. Corsetti, S. Matthews, N. A. Seager, S. Schmitz-Valckenberg, M. Fleckenstein, W. C. Hubbard, J. Thomas, J. L. Hageman, B. L. Williams, G. S. Hageman   +14 more
doaj   +1 more source

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

The Journal of Physiology, Volume 604, Issue 16, Page 6704-6730, 15 August 2026.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa, Jack R. T. Darby, Ashley S. Meakin, Mitchell C. Lock, Steven K. S. Cho, Christopher K. Macgowan, Mike. Seed, Michael D. Wiese, Janna L. Morrison   +8 more
wiley   +1 more source

Complement Gene Variants Define the Conformational Dynamics of C3 Convertase

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Multidisciplinary data have significantly advanced our understanding of C3bBb molecular dynamics. This review specifically contextualizes the functional impact of disease‐associated genetic variants, demonstrating that clinical genetics not only supports the current C3bBb model but also provides novel insights into previously undefined molecular ...
Héctor Martín Merinero, Seth J. Welsh, Zhen Xu, Richard J. H. Smith, Yuzhou Zhang   +4 more
wiley   +1 more source

Human Factor H-related Protein 5 (FHR-5) [PDF]

Journal of Biological Chemistry, 2001
Jennifer L. McRae, Peter J. Cowan, David A. Power, Ken I. Mitchelhill, Bruce E. Kemp, B. Paul Morgan, Brendan F. Murphy   +6 more
openaire   +1 more source

The Human Factor H-related Protein 4 (FHR-4) [PDF]

Journal of Biological Chemistry, 1997
Christine Skerka, Jens Hellwage, Wilfried Weber, Anne Tilkorn, Friedrich Buck, Thomas Marti, Eva Kampen, Ulrike Beisiegel, Peter F. Zipfel   +8 more
openaire   +1 more source

Editorial: Function and Dysfunction of Complement Factor H

Frontiers in Immunology, 2022
Mihály Józsi, Paul Nigel Barlow, Seppo Meri   +2 more
doaj   +1 more source