Results 231 to 240 of about 3,567,577 (243)

Proof of concept of a new plasma complement Factor H from waste plasma fraction. [PDF]

Front Immunol
Mori F, Pascali G, Berra S, Lazzarotti A, Panetta D, Rocchiccioli S, Ceccherini E, Norelli F, Morlando A, Donadelli R, Clivio A, Farina C, Noris M, Salvadori PA, Remuzzi G.   +14 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mapping the interaction sites of human and avian influenza A viruses and complement factor H. [PDF]

Front Immunol
Rabeeah I, Billington E, Nal B, Sadeyen JR, Pathan AA, Iqbal M, Temperton NJ, Zipfel PF, Skerka C, Kishore U, Shelton H.   +10 more
europepmc   +1 more source

The SCR-17 and SCR-18 glycans in human complement factor H enhance its regulatory function. [PDF]

J Biol Chem
Gao X, Iqbal H, Yu DQ, Gor J, Coker AR, Perkins SJ.   +5 more
europepmc   +1 more source

Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial. [PDF]

Nat Commun
Clarke JM, Simon GR, Mamdani H, Gu L, Herndon JE, Stinchcombe TE, Ready N, Crawford J, Sonpavde G, Balevic S, Nixon AB, Campa M, Gottlin EB, Li H, Saxena R, He YW, Antonia S, Patz EF.   +17 more
europepmc   +1 more source

SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis. [PDF]

Emerg Microbes Infect
Gebetsberger L, Malekshahi Z, Teutsch A, Tajti G, Fontaine F, Marella N, Mueller A, Prantl L, Stockinger H, Stoiber H, Ohradanova-Repic A.   +10 more
europepmc   +1 more source

Association of complement factor H gene polymorphisms with age-related macular egeneration susceptibility.

, 2015
Xiaofeng Hao, Like Xie, You-Zhi Tang, Wankun Xie, Zhifang Zhang, Yi-Xin Qi, Wen-Zheng Xiao, Jing Zhang   +7 more
openalex   +1 more source

Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis.

, 2013
Dongqing Yuan, Qin Yang, Xiaoyi Liu, Donglan Yuan, Songtao Yuan, Ping Xie, Qinghuai Liu   +6 more
openalex   +1 more source