Results 251 to 260 of about 14,538,270 (379)

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Pharmacokinetic model-based assessment of factor IX prophylaxis treatment regimens in severe hemophilia B. [PDF]

Sci Rep
Vandewalle B, Castaman G, Álvarez-Román MT, Ettingshausen CE, Nemes L, Tomic R, Martins P, Rodrigues JF, Pinachyan K.   +8 more
europepmc   +1 more source

Evidence for factor IX‐independent roles for factor XIa in blood coagulation

Journal of Thrombosis and Haemostasis, 2013
A. Matafonov, A. Matafonov, Qiufang Cheng, Yipeng Geng, I. Verhamme, Obi Umunakwe, E. Tucker, Mao-fu Sun, Vladimir Serebrov, A. Gruber, David Gailani   +10 more
semanticscholar   +1 more source

Comparative Wear and Friction Analysis of Sliding Surface Materials for Hydrostatic Bearing under Oil Supply Failure Conditions

Advanced Engineering Materials, EarlyView.
Hydrostatic bearings excel in high‐precision applications, but their performance hinges on a continuous external supply. This study evaluates various material combinations for sliding surfaces to mitigate damage during supply failures or misalignment and to discover the most effective materials identified for enhancing the reliability and efficiency of
Michal Michalec, Lukáš Daněk, Jan Foltýn, Petr Svoboda, Carsten Gachot, Martin Hartl, Ivan Křupka   +6 more
wiley   +1 more source

Significant PK variability of plasma-derived FIX concentrates in chinese children with Haemophilia B: A fixed single-dose study of factor IX-CTBB. [PDF]

Glob Med Genet
Liu G, Ai D, Li G, Zhen Y, Wu X, Yao W, Wei Y, Li Z, Zhou Y, Wu R, Chen Z.   +10 more
europepmc   +1 more source

Factor IX(a) inhibitors: an updated patent review (2003-present). [PDF]

Expert Opin Ther Pat, 2022
Afosah DK, Ofori E, Mottamal M, Al-Horani RA.   +3 more
europepmc   +1 more source

Use of a BamHI polymorphism in the factor IX gene for the determination of hemophilia B carrier status [PDF]

, 1986
CW Hay, KA Robertson, S-L. Yong, AR Thompson, GH Growe, RT MacGillivray   +5 more
openalex   +1 more source

Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer.

Blood, 2012
G. Buchlis, G. Podsakoff, A. Radu, S. Hawk, A. Flake, F. Mingozzi, K. High   +6 more
semanticscholar   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients.

Blood, 2012
A. Shapiro, M. Ragni, L. Valentino, N. Key, N. Josephson, J. Powell, G. Cheng, A. Thompson, Jaya Goyal, K. Tubridy, R. Peters, J. Dumont, D. Euwart, Lian Li, B. Hallén, P. Gozzi, A. Bitonti, Haiyan Jiang, A. Luk, G. Pierce   +19 more
semanticscholar   +1 more source