Results 121 to 130 of about 655,147 (306)

Effectiveness of 2D fingerprints for scaffold hopping

, 2011
Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J., Holliday, J.D., O'Dowd, C., Willett, P.   +3 more
core   +1 more source

Exploring the Effects of Factor Xa Inhibitors on Thrombin Generation in People with Haemophilia

, 2023
Caroline Dix, James D. McFadyen, Huyen Tran   +2 more
openalex   +1 more source

Anticoagulant treatment: the end of the old agents?

Swiss Medical Weekly, 2012
New oral anticoagulants used as single target inhibitors of coagulation enzymes have been developed and tested in extensive trial programmes. Results of most of these trials showed non-inferior and/or superior efficacy and safety compared to ...
Lukas Graf, Dimitrios A Tsakiris
doaj   +1 more source

Comparison of effectiveness and safety between uninterrupted direct oral anticoagulants with and without switching to dabigatran in atrial fibrillation ablation

Journal of Arrhythmia, 2020
Introduction Recent studies have demonstrated the feasibility of uninterrupted direct oral anticoagulants (DOACs) with a temporary switch to dabigatran (“dabigatran bridge”) for atrial fibrillation (AF) ablation.
Masahide Harada, Yuji Motoike, Yoshihiro Nomura, Asuka Nishimura, Masayuki Koshikawa, Kazuhiro Murayama, Yoshiharu Ohno, Eiichi Watanabe, Hideo Izawa, Yukio Ozaki   +9 more
doaj   +1 more source

The ISFET based heparin sensor with a monolayer of protamine as affinity ligand [PDF]

, 1995
The ion-step measuring method was used to determine absolute heparin concentrations in PBS and blood plasma with a Ta2O5 ISFET on to which a monolayer of protamine had been immobilized. Heparin is a highly negatively charged polysaccharide, which is used
Bergveld, P., Kerkhof, J.C. van, Schasfoort, R.B.M.   +2 more
core   +2 more sources

Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage

Neurocritical Care, 2021
Abdalla A. Ammar, Mahmoud A. Ammar, K. Owusu, Stacy C. Brown, F. Kaddouh, Aladine A. Elsamadicy, J. Acosta, G. Falcone   +7 more
semanticscholar   +1 more source

What Difference Does Language Make? Comparing Systematic Evidence Reviews of Vietnamese and English Language Literatures on Climate Change and the Health of Outdoor Workers

Area, EarlyView.
Short Abstract This paper compares two systematic literature reviews—one in English and one in Vietnamese—to examine how language shapes the production and framing of knowledge on climate change and health. It highlights significant differences in methods, assumptions and policy framings, and argues that linguistic boundaries are not just technical ...
Anh Ngoc Vu, Jonathan Rigg, Felicity Kersting, Ekaterina Tarnovskaya, Loc Duc Nguyen   +4 more
wiley   +1 more source

Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization [PDF]

, 2016
Objectives: In the presence of a chronically occluded coronary artery, the collateral circulation matures by a process of arteriogenesis; however, there is considerable variation between individuals in the functional capacity of that collateral network ...
Alamgir, Farquad, Cunnington, Michael S., Ettelaie, Camille, Hoye, Angela, Ladwiniec, Andrew, Rossington, Jennifer, Thackray, Simon   +6 more
core   +1 more source

Semaglutide and tirzepatide effects on cardiovascular outcomes in people with overweight or obesity in the real world (STEER)

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To assess the real‐world effectiveness of semaglutide versus tirzepatide in reducing major adverse cardiovascular events (MACE) among patients with overweight/obesity and established atherosclerotic cardiovascular disease (ASCVD) without diabetes in an insured US population.
Lauren Wilson, Zhenxiang Zhao, Victoria Divino, Matthew Bassan, Bríain Ó. Hartaigh, Signe Stensen, Kerem Ozer   +6 more
wiley   +1 more source

Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani, Chee Wee Tan, Deborah M. Siegal   +2 more
wiley   +1 more source