Results 131 to 140 of about 1,150,824 (292)

The Impact of Speed and Bias on the Cognitive Processes of Experts and Novices in Medical Image Decision-making [PDF]

open access: yesarXiv, 2017
Training individuals to make accurate decisions from medical images is a critical component of education in diagnostic pathology. We describe a joint experimental and computational modeling approach to examine the similarities and differences in the cognitive processes of novice participants and experienced participants (pathology residents and ...
arxiv  

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

open access: yesFEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda   +15 more
wiley   +1 more source

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

open access: yesFEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei   +6 more
wiley   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

open access: yesFEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel   +4 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

The effect of kV imaging dose on PTV and OAR planning constraints in lung SBRT using stereoscopic/monoscopic real‐time tumor‐monitoring system

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Quantify the impact of additional imaging doses on clinical dose constraints during lung stereotactic body radiotherapy (SBRT) treatment utilizing stereoscopic/monoscopic real‐time tumor monitoring. Materials and Methods Thirty lung SBRT patients treated with the volumetric arc therapy technique were randomly selected from the ...
Ruwan Abeywardhana, Mike Sattarivand
wiley   +1 more source

Feasibility study of skin dosimetry with TLD sheets for measuring the effect of 3D printed bolus in radiotherapy

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract The thermoluminescence dosimeter (TLD) sheet is a measurement device coated with manganese‐doped LiB3O5 in sheet form. The sheet is 0.2‐mm thick and flexible. Hence, it can fit and be installed on irregular surfaces. The current study aimed to evaluate the feasibility of measuring patient surface doses during radiation therapy using TLD sheets.
Yuya Miyasaka   +8 more
wiley   +1 more source

Coaching by design: exploring a new approach to faculty development in a competency-based medical education curriculum

open access: yesAdvances in Medical Education and Practice, 2019
Christine J Orr,1 Ranil R Sonnadara21Discipline of Medicine, Memorial University of Newfoundland, St. John’s Newfoundland and Labrador, Canada; 2Department of Surgery, McMaster University, Hamilton, ON, CanadaAbstract: As curricula move from a time-
Orr CJ, Sonnadara RR
doaj  

Medical school faculty productivity

open access: yesAcademic Medicine, 1976
E H Peeples   +3 more
openaire   +4 more sources

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