Results 101 to 110 of about 219,223 (326)

Schubert Polynomials and Quiver Formulas [PDF]

, 2002
The work of Buch and Fulton established a formula for a general kind of degeneracy locus associated to an oriented quiver of type $A$. The main ingredients in this formula are Schur determinants and certain integers, the quiver coefficients, which ...
Buch, Anders Skovsted, Kresch, Andrew, Tamvakis, Harry, Yong, Alexander   +3 more
core   +3 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival

Frontiers in Oncology
IntroductionAdvanced thyroid cancer, including papillary (PTC) and anaplastic thyroid cancer (ATC), are the leading causes of endocrine cancer deaths. Thus, there is a critical need to identify novel therapeutic targets to improve standard of care. Focal
Meghan D. Kellett, Vibha Sharma, Madeline E. Sherlock, Umarani Pugazhenthi, Madison M. Rose, Molishree U. Joshi, Molishree U. Joshi, Monika Dzieciatkowska, Vu Nguyen, Philip Reigan, Kirk C. Hansen, Jeffrey S. Kieft, Rebecca E. Schweppe, Rebecca E. Schweppe   +13 more
doaj   +1 more source

Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions

Frontiers in Physiology, 2014
TonEBP/NFAT5 is a major regulator of the urinary concentrating process and is essential for the osmoadaptation of renal medullary cells. Focal adhesion kinase (FAK) is a mechanosensitive non-receptor protein tyrosine kinase expressed abundantly in the ...
Wolfgang eNeuhofer
doaj   +1 more source

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Biomolecules, 2020
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez, Pilar López Navajas, Daniel Lietha   +2 more
doaj   +1 more source

Open group transformations [PDF]

, 1999
Open groups whose generators are in arbitrary involutions may be quantized within a ghost extended framework in terms of a nilpotent BFV-BRST charge operator.
Batalin, Igor, Marnelius, Robert
core   +4 more sources

Deconstructing FAK function

Journal of Cell Biology, 2010
Focal adhesion kinase (FAK) has multiple functions in endothelial cells, but only some of them require the protein's kinase activity, [Zhao et al.][1] report. ![Figure][2] Apoptotic cells (red) are found in blood vessels (green) lacking FAK (left), but are absent from vessels expressing ...
openaire   +2 more sources

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source

Attitudes and entrepreneurship behaviors of students of Józef Piłsudski University of Physical Education in Warsaw

Journal of Education, Health and Sport, 2017
Entrepreneurship is a major competency on the labour market. The goal was, first of all, to recognize the extent to which students are characterized by entrepreneurship. The diagnostic survey method has been applied to gather necessary empirical evidence.
Tadeusz Fąk, Paulina Jarecka
doaj   +1 more source

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena, Bukin, Eugenij, Friedl, Peter, Gröger, Marion, Hofer-Warbinek, Renate, Ignatyev, George, Knapp, Sylvia, Matt, Ulrich, Pasteiner, Waltraud, Petzelbauer, Peter, Reingruber, Sonja, Zacharowski, Kai, Zinkl, Daniela   +12 more
core