Results 31 to 40 of about 219,223 (326)
Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt
Biomolecular Concepts, 2015 Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function. Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3 ...
Niit Maximilian +6 more
doaj +1 more source
Roton-Phonon Interactions in Superfluid 4He [PDF]
, 2012 High-resolution neutron resonance spin-echo measurements of superfluid 4He show that the roton energy does not have the same temperature dependence as the inverse lifetime. Diagrammatic analysis attributes this to the interaction of rotons with thermally
Chernyshev, A. L. +3 more
core +2 more sources
Leptin induces cell migration and invasion in a FAK-Src-dependent manner in breast cancer cells
Endocrine Connections, 2019 Breast cancer is the most common invasive neoplasia, and the second leading cause of the cancer deaths in women worldwide. Mammary tumorigenesis is severely linked to obesity, one potential connection is leptin. Leptin is a hormone secreted by adipocytes,
Juan Carlos Juárez-Cruz +9 more
doaj +1 more source
In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate. [PDF]
, 2017 We investigated the physical role of the extracellular matrix (ECM) in vascular homeostasis in the basal chordate Botryllus schlosseri, which has a large, transparent, extracorporeal vascular network encompassing an area >100 cm2 We found that the ...
Boyer, Scott W +9 more
core +1 more source
Focal adhesion kinase: Insight into molecular roles and functions in hepatocellular carcinoma [PDF]
, 2017 Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Due to the high incidence of post-operative recurrence after current treatments, the identification of new and more effective drugs is required.
Alisi, Anna +4 more
core +2 more sources
Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth [PDF]
, 2011 Background: Focal adhesion kinase (FAK) functions in cell migration and signaling through activation of the mitogen-activated protein kinase (MAPK) signaling cascade.
Chen, Ruey-Hwa +11 more
core +1 more source
Getting One's Fak Straight [PDF]
Developmental Cell, 2010 Focal adhesion kinase (FAK) is a pivotal regulator of integrin signaling and responses to cell adhesive dynamics. In this issue of Developmental Cell, Ashton et al. demonstrate that Fak is critical for intestinal oncogenesis and regeneration after injury but not for day-to-day homeostasis, providing novel insights into intestinal biology and colorectal
openaire +2 more sources
Cell Death and Disease, 2022 Acute lung injury (ALI), characterized by inflammatory damage, is a major clinical challenge. Developing specific treatment options for ALI requires the identification of novel targetable signaling pathways.
Xi Chen +9 more
doaj +1 more source
Bone & Joint ResearchAims: Osteosarcoma is the most common primary bone malignancy among children and adolescents. We investigated whether benzamil, an amiloride analogue and sodium-calcium exchange blocker, may exhibit therapeutic potential for osteosarcoma in vitro ...
Meng-Chieh Lin +8 more
doaj +1 more source
FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer
Biomedicines, 2021 Triple-negative breast cancer (TNBC) remains a significant clinical challenge because of its high vascularity and metastatic and recurrent rates.
Jun-Ping Shiau +9 more
doaj +1 more source