Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]
, 2007 Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Achiwa H +10 more
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FAK and p53 Protein Interactions [PDF]
Anti-Cancer Agents in Medicinal Chemistry, 2011 Focal Adhesion Kinase plays a major role in cell adhesion, motility, survival, proliferation, metastasis, angiogenesis and lymphangiogenesis. In 2004, we have cloned the promoter sequence of FAK and found that p53 inhibits its activity (BBA, v. 1678, 2004).
Vita M, Golubovskaya, William G, Cance
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Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation
Cell Structure and FunctionDuring early embryogenesis, gastrulation occurs within a specific region of the pluripotent epiblast, where cells undergo significant changes in their context.
Sae Nozaki, Taisei Mihara, Yohei Hirai
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The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET. [PDF]
PLoS ONE, 2013 FAK and Src signaling play important roles in cell differentiation, survival and migration. However, it remains unclear how FAK and Src activities are regulated at the initial stage of stem cell differentiation.
Xiaoling Liao +8 more
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Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion [PDF]
, 2009 Background Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and ...
Bu Yahao, Gelman Irwin H, Sachdev Sanjay
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ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald +2 more
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The Journal of Cell Biology, 2008 ![Graphic][1] Because their back ends get stuck, cells missing FAK and Pyk2 stretch until they break. To decipher how cells crawl, researchers have knocked out a key signaling protein known as focal adhesion kinase (FAK), which relays messages from the cell surface.
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FAK nuclear export signal sequences [PDF]
FEBS Letters, 2008 Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only ...
Ossovskaya, Valeria +4 more
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FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. [PDF]
PLoS ONE, 2011 Following damage to the intestinal epithelium, restoration of epithelial barrier integrity is triggered by a robust proliferative response. In other tissues, focal adhesion kinase (FAK) regulates many of the cellular processes that are critical for ...
Katherine A Owen +4 more
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FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. [PDF]
, 2019 Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence.
Anderson, Kristen +30 more
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