Results 31 to 40 of about 21,448 (228)

Vaccines for cancer interception in familial adenomatous polyposis [PDF]

Frontiers in Immunology
Mary L Disis, Disis Mary L
exaly   +2 more sources

“De novo” familial adenomatous polyposis (FAP) presenting as rectal cancer

Clinical Case Reports, 2021
Familial adenomatous polyposis is an autosomal dominant disorder with familial predisposition. 25%‐30% cases arise "de novo," without any clinical or genetic evidence.
Riya Agrawal, Utpal De
doaj   +1 more source

Primary adenocarcinoma in the ileostomy of a woman with familial adenomatous polyposis: a case report and literature review

Journal of Medical Case Reports, 2011
Introduction Ileal adenomas associated with familial adenomatous polyposis are a common finding. Many recent studies following panproctocolectomy for familial adenomatous polyposis have confirmed the presence of multiple ileal adenomas and an increase in
Hammad Ahmed, Tayyem Raed, Milewski Peter J, Gunasekaran Shanmugavelu   +3 more
doaj   +1 more source

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus-ends and is involved in establishing parallel arrays of microtubule bundles in highly polarised epithelial cells [PDF]

, 2002
Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating ß-catenin levels in the Wnt signaling pathway, the APC protein is ...
John B. Mackie, Mackie, JB, Nathke, Inke S.; id_orcid, Prescott, AR, Nathke, IS, Mogensen, MM, Mette M. Mogensen, Prescott, Alan R.; id_orcid, Mackie, John B., Tucker, John B., Inke S. Näthke, Näthke, Inke S., John B. Tucker, Mogensen, Mette M., Prescott, Alan R., Alan R. Prescott, Tucker, John Barry   +16 more
core   +1 more source

Desmoids in familial adenomatous polyposis

Journal of British Surgery, 1996
Abstract Clinical desmoid disease affects approximately 10 per cent of patients with familial adenomatous polyposis (FAP); the subclinical rate is unknown. Desmoids are probably neoplastic rather than regenerative in origin and may arise in association with germline or somatic mutations at or beyond codon 1444 of the APC gene.
S K, Clark, R K, Phillips
openaire   +2 more sources

Chemoprevention in familial adenomatous polyposis [PDF]

Best Practice & Research Clinical Gastroenterology, 2011
Familial adenomatous polyposis (FAP) predictably leads to adenomas and eventual adenocarcinomas in the lower gastrointestinal tract and less frequently, the upper gastrointestinal tract. Chemopreventive strategies have been studied in FAP patients to delay the development of adenomas in the upper and lower gastrointestinal tract, as well as to prevent ...
Brian, Kim, Francis M, Giardiello
openaire   +2 more sources

Familial polyposis coli: the management of desmoid tumor bleeding

Open Medicine, 2019
There is currently no standard treatment for desmoid tumors (DTs) associated with familial polyposis coli (FAP). Familial adenomatous polyposis in DT patients is sometimes a life-threatening condition.
Calogero Armando, Sagnelli Caterina, Carlomagno Nicola, Tammaro Vincenzo, Candida Maria, Vernillo Antonio, Peluso Gaia, Minieri Gianluca, Sica Antonello, Ciccozzi Massimo, Santangelo Michele, Dodaro Concetta Anna   +11 more
doaj   +1 more source

Familial adenomatous polyposis in China

Oncology Letters, 2016
Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a poor prognosis, and has been studied by clinicians and geneticists in China for the past three decades. It is estimated that FAP has an incidence of between 1 in 8,000 and 1 in 10,000 individuals, and accounts for 0.94% of colorectal cancer cases in China.
Jun, Yang, Qing Wei, Liu, Liang Wen, Li, Qiang Zhi, Wang, Min, Hong, Jian, Dong   +5 more
openaire   +3 more sources

The Genomics of colorectal cancer: State of the art

, 2008
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
Hodgson, SV, Hodgson, Shirley V, Beggs, AD, Beggs, Andrew D; id_orcid   +3 more
core   +1 more source

Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo [PDF]

, 2010
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele
Newton, Ian P., Jarnicki, Andrew G., Nathke, Inke S.; id_orcid, Sansom, Owen, Nathke, I., Samuel, M., Suzuki, Hiromu, Tosh, David, Abud, H E, Newton, IP, Huelsken, J, Stacker, SA, Samuel, M S, Buchert, M, Ernst, M., Stacker, Steven, Stacker, S., Dimitris Athineos, Alan R Clarke, Newton Ian P., Helen E. Abud, Heath, JK, Abud Helen E., Clarke Alan R., Suzuki, H., Faux, Maree, Newton, I., Jarnicki, A.G., Meniel, VS, Michael Buchert, Ernst, Matthias, Sansom, Owen J., Sansom Owen J., Meniel, Valerie, Clarke, Alan R., Burke, Z D, Ian P Newton, Inke S Näthke, David Tosh, Näthke, I.S., Winbanks, Catherine, Ian P. Newton, Sansom, O J, Burke, Z., Samuel Michael S., Samuel, M.S., Näthke Inke S., Inke S. Näthke, Jarnicki, A G, Abud, H.E., Tosh, D, Burke, ZD, Catherine E Winbanks, Samuel, Michael S., Heath Joan K., Andrew G Jarnicki, Nusse, R., Jarnicki, Andrew, Meniel, V.S., Abud, H., Samuel, MS, Joan K Heath, Winbanks, C E, Clarke, A R, Winbanks, C.E., Suzuki Hiromu, Winbanks Catherine E., Clarke, Alan Richard, Clarke, A.R., Joerg Huelsken, Stacker, Steven A., Helen E Abud, Alan R. Clarke, Buchert, M., Owen J. Sansom, Abud, HE, Joan K. Heath, Faux Maree C., Jarnicki, AG, Owen J Sansom, Athineos Dimitris, Suzuki, H, Faux, M., Winbanks, C., Matthias Ernst, Huelsken Joerg, Athineos, D, Sansom, O.J., Burke, Zoe D., Meniel Valerie S., Huelsken, J., Tosh David, Newton, I.P., Samuel, Michael, Athineos, Dimitris, Ernst Matthias, Jarnicki Andrew G., Zoe D Burke, Stacker, S.A., Stacker, S A, Clarke, Alan, Buchert, Michael, Abud, Helen E., Michael S. Samuel, Jarnicki, A., Steven A Stacker, Meniel, Valerie S., Faux, M C, Athineos, D., Meniel, V., Ernst, M, Michael S Samuel, Heath, Joan K., Nathke, I S, Sansom, OJ, Newton, Ian, Tosh, D., Valerie S. Meniel, Clarke, AR, Newton, I P, Näthke, Inke S., Meniel, V S, Valerie S Meniel, Buchert Michael, Newton, Ian P, Heath, Joan, Maree C Faux, Näthke, IS, Burke, Z.D., Heath, J., Maree C. Faux, Faux, Maree C., Winbanks, Catherine E., Heath, J K, Faux, M.C., Abud, Helen, Catherine E. Winbanks, Faux, MC, Sansom, O., Burke, Zoe, Andrew G. Jarnicki, Steven A. Stacker, Hiromu Suzuki, Zoe D. Burke, Huelsken, Joerg, Heath, J.K., Stacker Steven A., Burke Zoe D., Winbanks, CE, Nathke, Inke, Clarke, A.   +150 more
core   +1 more source