Results 51 to 60 of about 18,649 (196)

A case report of non‐syndromic colonic ganglioneuroma in a patient with juvenile polyposis

JPGN Reports, EarlyView.
Abstract Colonic ganglioneuromas in children are rare, particularly without associated hereditary syndromes like multiple endocrine neoplasia (MEN2B), neurofibromatosis type 1(NF1), or Phosphatase and tensin homolog hamartoma tumor syndrome (PHTS). We report a 12‐year‐old male with a history of juvenile polyposis syndrome (JPS) and segmental colonic ...
Holly Coffey, Kshitij Arora, Matthew J. Giefer   +2 more
wiley   +1 more source

A Patient With Desmoid Tumors and Familial FAP Having Frame Shift Mutation of the APC Gene

Acta Medica Iranica, 2017
Desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (FAP) as an extra-colonic manifestation of the disease.
Sanambar Sadighi, Mahsa Ghaffari-Moghaddam, Mojtaba Saffari, Mohammad Ali Mohagheghi, Reza Shirkoohi   +4 more
doaj  

The link between colon cancer and congenital hypertrophy of the retinal pigment epithelium (CHRPE)

American Journal of Ophthalmology Case Reports, 2019
Purpose: Clarify the differences between Familial Adenomatous Polyposis (FAP)-associated Congenital Hypertrophy of the Retinal Epithelium (CHRPE) and benign variants with regards to lesion characteristics and associated risk.
Brent Deibert, Letisha Ferris, Noel Sanchez, Paul Weishaar   +3 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

CD36 – a plausible modifier of disease phenotype in familial adenomatous polyposis

Hereditary Cancer in Clinical Practice, 2018
Background Familial adenomatous polyposis (FAP) is a well characterised genetic predisposition to early onset colorectal cancer (CRC) that is characterised by polyposis of the colon and rectum.
Merran Holmes, Toni Connor, Christopher Oldmeadow, Peter G. Pockney, Rodney J. Scott, Bente A. Talseth-Palmer   +5 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

The Microbiota Profile in Inflamed and Non-Inflamed Ileal Pouch–Anal Anastomosis

Microorganisms, 2020
The objective was to determine the bacterial composition in inflamed and non-inflamed pouches for comparison to the microbiota of healthy individuals.
Sabrina Just Kousgaard, Thomas Yssing Michaelsen, Hans Linde Nielsen, Karina Frahm Kirk, Mads Albertsen, Ole Thorlacius-Ussing   +5 more
doaj   +1 more source

Distinct Symptom Occurrence Subgroups Among Patients With Colorectal Cancer: Differences in Social Determinants of Health and Diet Quality

Research in Nursing &Health, EarlyView.
ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer mortality in the United States. Many patients with CRC experience physical and psychological symptoms that diminish quality of life and are shaped by social determinants of health (SDOH) and diet quality.
Youran Lee, Qing Yang, Melissa Kay, Donald E. Bailey, Biljana Gigic, Sheetal Hardikar, Adetunji T. Toriola, David Shibata, Christopher I. Li, Doratha A. Byrd, Jane C. Figueiredo, Ildiko Strehli, Megan Mclaws, Vaia Florou, Mmadili Ilozumba, Patricia Erickson, Apurva Medhe, Cornelia M. Ulrich, Rosa M. Gonzalez‐Guarda   +18 more
wiley   +1 more source

Pathogenic APC Variants in Latvian Familial Adenomatous Polyposis Patients

Medicina, 2019
Background and objectives: Familial adenomatous polyposis is one of the APC-associated polyposis conditions described as genetically predetermined colorectal polyposis syndrome with a variety of symptoms.
Zanda Daneberga, Dace Berzina, Viktors Borosenko, Zita Krumina, Linda Kokaine-Sapovalova, Andris Gardovskis, Egija Berga-Svitina, Janis Gardovskis, Edvins Miklasevics   +8 more
doaj   +1 more source

Predictors of reduced length of stay in minimally invasive colectomy, a 20‐year study

Surgical Practice, EarlyView.
Abstract Purpose Minimally invasive colorectal resection is a common surgical procedure indicated for a variety of malignant and benign conditions. Length of stay (los) is an important metric in the evaluation of surgical care quality and healthcare expenditure.
Elisa Tran, Angel Hayes, Amy Cao, Andrew Stevenson, David Clark   +4 more
wiley   +1 more source