Results 71 to 80 of about 33,043 (222)

Availability Of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis [PDF]

, 2014
Background: Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant colorectal cancer predisposition associated with the development of hundreds to thousands of adenomatous colorectal polyps beginning in childhood or ...
Lewis, Andrea M
core  

Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families [PDF]

, 2015
BACKGROUND: The overwhelming majority (approximately 80%) of individuals with classic familial adenomatous polyposis (FAP) exhibit mutations in the coding sequence of the adenomatous polyposis coli (APC) tumor suppressor gene. Families without detectable
Baxter, Melanie D, Chapman, William C, Davidson, Nicholas O, Goodfellow, Paul J, Kennedy, Susan M, Lin, Lawrence, Lin, Shin, Lin, Yiing, Zhang, Zhengyan   +8 more
core   +2 more sources

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2‐p53 Pathway and M2 Macrophage Polarization

Cancer Science, EarlyView.
SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng, You Zhou, Sijie Song, Hongtao Liu, Siqi Liao, Li Zhou, Siyuan Chen, Zhihang Zhou, Song He, Bingrong Liu   +9 more
wiley   +1 more source

Pathogenic APC Variants in Latvian Familial Adenomatous Polyposis Patients

Medicina, 2019
Background and objectives: Familial adenomatous polyposis is one of the APC-associated polyposis conditions described as genetically predetermined colorectal polyposis syndrome with a variety of symptoms.
Zanda Daneberga, Dace Berzina, Viktors Borosenko, Zita Krumina, Linda Kokaine-Sapovalova, Andris Gardovskis, Egija Berga-Svitina, Janis Gardovskis, Edvins Miklasevics   +8 more
doaj   +1 more source

Impact of Computer‐Aided Detection on Endoscopist's Gaze‐Shift Distance During Colonoscopy: a Randomized Controlled Trial (With Video)

Journal of Gastroenterology and Hepatology, EarlyView.
CADe assistance did not significantly change the gaze‐shift distance overall, but it reduced gaze‐shift distance among CADe‐experienced endoscopists. CADe may be associated with reduced eye strain, depending on the endoscopist's CADe experience. ABSTRACT Background and Aim Computer‐aided detection (CADe) facilitates colorectal lesion detection, but it ...
Shun Ito, Fumiaki Ishibashi, Kosuke Okusa, Kentaro Mochida, Takao Tonishi, Eri Ozaki, Sho Suzuki   +6 more
wiley   +1 more source

MutYH-associated polyposis [PDF]

Терапевтический архив, 2019
MutYH-associated polyposis is the only polyposis syndrome with an autosomal recessive type of inheritance, often phenotypically similar to a weakened form of familial adenomatous polyposis.
M Kh Toboeva, Yu A Shelygin, S A Frolov, M A Kuzminov, A S Tsukanov   +4 more
doaj   +1 more source

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases

, 2015
BACKGROUND: In 30-50% of patients with colorectal adenomatous polyposis, no germline mutation in the known genes APC, causing familial adenomatous polyposis, MUTYH, causing MUTYH-associated polyposis, or POLE or POLD1, causing polymerase-proofreading ...
Adam, R., Aretz, S., Becker, T., Drichel, D., Hoffmann, P., Holinski-Feder, E., Holzapfel, S., Horpaopan, S., Kerick, M., Kirfel, J., Kristiansen, G., Laner, A., Lifton, R., Nöthen, M., Perner, S., Peters, S., Schweiger, M., Spier, I., Timmermann, B., Zhao, B.   +19 more
core   +1 more source

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source