Results 71 to 80 of about 21,448 (228)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

A Patient With Desmoid Tumors and Familial FAP Having Frame Shift Mutation of the APC Gene

Acta Medica Iranica, 2017
Desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (FAP) as an extra-colonic manifestation of the disease.
Sanambar Sadighi, Mahsa Ghaffari-Moghaddam, Mojtaba Saffari, Mohammad Ali Mohagheghi, Reza Shirkoohi   +4 more
doaj  

The Microbiota Profile in Inflamed and Non-Inflamed Ileal Pouch–Anal Anastomosis

Microorganisms, 2020
The objective was to determine the bacterial composition in inflamed and non-inflamed pouches for comparison to the microbiota of healthy individuals.
Sabrina Just Kousgaard, Thomas Yssing Michaelsen, Hans Linde Nielsen, Karina Frahm Kirk, Mads Albertsen, Ole Thorlacius-Ussing   +5 more
doaj   +1 more source

Distinct Symptom Occurrence Subgroups Among Patients With Colorectal Cancer: Differences in Social Determinants of Health and Diet Quality

Research in Nursing &Health, EarlyView.
ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer mortality in the United States. Many patients with CRC experience physical and psychological symptoms that diminish quality of life and are shaped by social determinants of health (SDOH) and diet quality.
Youran Lee, Qing Yang, Melissa Kay, Donald E. Bailey, Biljana Gigic, Sheetal Hardikar, Adetunji T. Toriola, David Shibata, Christopher I. Li, Doratha A. Byrd, Jane C. Figueiredo, Ildiko Strehli, Megan Mclaws, Vaia Florou, Mmadili Ilozumba, Patricia Erickson, Apurva Medhe, Cornelia M. Ulrich, Rosa M. Gonzalez‐Guarda   +18 more
wiley   +1 more source

Dispelling misconceptions in the management of familial adenomatous polyposis [PDF]

, 2017
Patients with familial adenomatous polyposis require surgical intervention at some point in their lives. The diagnosis is often apparent from their phenotype and family history, however, this is not always the case.
Matthew Kalady, Timothy J. Chittleborough, Warrier, SK, Kalady, M, Satish K. Warrier, Church, J, James Church, Chittleborough, TJ, Alexander G. Heriot, Heriot, AG   +9 more
core   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, EarlyView.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis [PDF]

, 2018
Familial adenomatous polyposis (FAP) is usually caused by germline mutations in the adenomatous polyposis coli (APC) gene. The classic form is characterized by hundreds to thousands of adenomas in the colorectum and early onset colorectal cancer (CRC) if
Eli Marie Grindedal, Hølmebakk, Toto, Toto Hølmebakk, Norum, Ole-Jacob Anderssen, Åberg, Kristin, Astrid Tenden Stormorken, Stormorken, Astrid T., Kristin Aaberg, Berg, Thomas, Grindedal, Eli Marie, Steigen, Sonja Eriksson, Ole-Jacob Norum, Thomas Berg, Sonja E. Steigen   +13 more
core   +1 more source

MutYH-associated polyposis [PDF]

Терапевтический архив, 2019
MutYH-associated polyposis is the only polyposis syndrome with an autosomal recessive type of inheritance, often phenotypically similar to a weakened form of familial adenomatous polyposis.
M Kh Toboeva, Yu A Shelygin, S A Frolov, M A Kuzminov, A S Tsukanov   +4 more
doaj   +1 more source

Predictors of reduced length of stay in minimally invasive colectomy, a 20‐year study

Surgical Practice, EarlyView.
Abstract Purpose Minimally invasive colorectal resection is a common surgical procedure indicated for a variety of malignant and benign conditions. Length of stay (los) is an important metric in the evaluation of surgical care quality and healthcare expenditure.
Elisa Tran, Angel Hayes, Amy Cao, Andrew Stevenson, David Clark   +4 more
wiley   +1 more source

Iatrogenic pancreatitis in familial adenomatous polyposis

, 1993
The first case of a patient with familial adenomatous polyposis (FAP) who developed pancreatitis after routine screening and biopsy of the ampulia of Vater is described.
Phillips, R. K.S., Nugent, K. P., Williams, C. B., Spigelman, A. D.   +3 more
core   +1 more source