Results 91 to 100 of about 18,649 (196)

Intramucosal Colon Cancer Developing in an Inverted Hyperplastic Polyp

open access: yesGut and Liver, 2013
Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis with fewer than one hundred colorectal polyps and a later age of onset of the cancer. Here, we report two cases of AFAP within family members.
doaj   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo   +8 more
wiley   +1 more source

A Novel Germline Mutation in Exon 15 of the APC Gene in Attenuated Familial Adenomatous Polyposis: A Report of Two Cases

open access: yesGut and Liver, 2013
Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis with fewer than one hundred colorectal polyps and a later age of onset of the cancer. Here, we report two cases of AFAP within family members.
doaj   +1 more source

Endoscopic ischemic polypectomy for small intestinal polyps in a 7‐year‐old girl with juvenile polyposis syndrome

open access: yesJPGN Reports, Volume 7, Issue 3, Page 471-473, August 2026.
Abstract This is the first report of endoscopic ischemic polypectomy (EIP) for small intestinal polyps in a pediatric patient with juvenile polyposis syndrome (JPS). A 7‐year‐old girl underwent double‐balloon enteroscopy, during which 17 pedunculated polyps were treated using the crossed‐clip strangulation method without complications. Ten‐month follow‐
Shingo Kurasawa   +5 more
wiley   +1 more source

Smoker's Lungs: Quo Vadis? Exploring the Shared and Individual Smoking‐Related Molecular Pathways of Emphysema, Carcinoma, and Fibrosis – An Illustrative Review

open access: yesThoracic Cancer, Volume 17, Issue 16, August 2026.
Cigarette smoking is related to chronic epithelial injury, which represents a central initiating event in smoking‐related lung diseases: NSCLC (non‐small cell lung cancer), IPF (idiopathic pulmonary fibrosis), and emphysema. Altered lung biology and shared molecular pathways contribute to their pathogenesis.
Lovorka Grgurević   +5 more
wiley   +1 more source

AP‐1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids

open access: yesBiology of the Cell, Volume 118, Issue 8, August 2026.
We show that in mouse intestinal organoids, AP‐1B is implicated in apical polarity, differentiation in the secretory lineage and proliferation. In particular, we propose that proliferation is controlled by AP‐1B via the mTOR and YAP pathways. Arrows show the functional links that were elucidated in this study, and dotted lines show putative downstream ...
Maela Duclos   +5 more
wiley   +1 more source

Olfactory Ensheathing Cell Transplantation Combined With Electrical Epidural Stimulation as a Long‐Term Treatment for Severe Spinal Cord Injury in Female Fischer 344 Rats

open access: yesEuropean Journal of Neuroscience, Volume 64, Issue 4, August 2026.
This study combined two promising therapies, olfactory ensheathing cell (OEC) transplantation and electrical epidural stimulation, to help reestablish circuit connectivity following a complete, midthoracic spinal cord transection in inbred Fischer 344 rats (A, B).
Kaitlin L. Ingraham Dixie   +7 more
wiley   +1 more source

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

open access: yesJournal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

Familial Adenomatous Polyposis: An Update [PDF]

open access: yesJournal of the Royal Society of Medicine, 1996
A, Wyman, A J, Shorthouse
openaire   +2 more sources

The Molecular Pathology of Morules in Endometrial Carcinoma: Biological Significance and Clinical Implications

open access: yesPathology International, Volume 76, Issue 8, August 2026.
In Em Ca cells with harboring baseline CTNNB1 mutations, morular‐ and SqM‐related CSCs and mature SqM components develop sequentially through tightly orchestrated EMT and MET programs, a cascade favored under microenvironmental hypoxia. Conversely, in Em Ca cells displaying wild‐type CTNNB1, the tumor cells directly trans‐differentiate into a squamous ...
Makoto Saegusa
wiley   +1 more source

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