Results 101 to 110 of about 21,448 (228)

Functional outcomes in patients submitted to restorative proctocolectomy with ileal pouch anal anastomosis in a single tertiary center

Journal of Coloproctology, 2018
Background: Functional results after restorative proctocolectomy for ulcerative colitis and familial adenomatous polyposis are variable. We assessed functional results in patients with ileal pouch anal anastomosis and evaluated potential factors ...
Ana Cristina Silva, Mónica Sampaio, Ricardo Marcos-Pinto, Paula Lago, Anabela Rocha, Eduarda Matos, Marisa D. Santos   +6 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Desmoid Tumor In Patients With Familial Adenomatous Polyposis. [PDF]

, 2015
Desmoid tumors constitute one of the most important extraintestinal manifestations of familial adenomatous polyposis. The development of desmoids is responsible for increasing morbidity and mortality rates in cases of familial adenomatous polyposis.
Leal, Raquel Franco, Amstalden, Eliane M Ingrid, Silva, Patricia V V Tapia, Ayrizono, Maria de Lourdes Setsuko, Coy, Cláudio Saddy Rodrigues, Fagundes, João José   +5 more
core  

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1773-1782, August 2026.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman, Carli M. Tops, Jelmer Legebeke, Ting Yang, Marcos Díaz Gay, Diantha Terlouw, Lisa E. E. L. O. Lashley, Stefan Aretz, Anna K. Sommer, Mariona Terradas, Laura Valle, Richarda M. de Voer, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Maartje Nielsen   +15 more
wiley   +1 more source

Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes

Hereditary Cancer in Clinical Practice, 2003
There have been significant advances in our knowledge about the molecular changes that precede and accompany the development of inherited predispositions to colorectal cancer.
Scott Rodney J
doaj   +1 more source

Integration of Three‐Dimensional Cell Culture Techniques and Photobiomodulation for Supportive Differentiation of Adipose‐Derived Stem Cells into Smooth Muscle

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Photobiomodulation (PBM) has gained recognition as a promising, non‐invasive strategy to enhance the differentiation of adipose‐derived stem cells (ADSCs) into smooth muscle cells (SMCs), particularly when used together with a three‐dimensional (3D) hydrogel culture system.
Christevie Mbuyu, Heidi Abrahamse, Anine Crous   +2 more
wiley   +1 more source

Familial adenomatous polyposis: Diagnosis and surveillance strategies: Review article

, 2020
Familial adenomatous polyposis is characterized by over 100 colorectal adenomas in the colorectum. The disease equally affects both sexes, with an incidence estimated at 1.14025-1.8300.
Jokar, M.H., Aghaei, M., Mohamadkhani, A., Sedighi, S., Moradzadeh, M.   +4 more
core  

A porcine model of familial adenomatous polyposis.

, 2012
We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP).
Flisikowska, T;Merkl, C;Landmann, M;Eser, S;Rezaei, N;Cui, X;Kurome, M;Zakhartchenko, V;Kessler, B;Wieland, H;Rottmann, O;Schmid, RM;Schneider, G;Kind, A;Wolf, E;Saur, D;Schnieke, A, Flisikowska, Tatiana;Merkl, Claudia;Landmann, Martina;Eser, Stefan;Rezaei, Nousin;Cui, Xinxin;Kurome, Mayuko;Zakhartchenko, Valeri;Kessler, Barbara;Wieland, Hagen;Rottmann, Oswald;Schmid, Roland M.;Schneider, Günter;Kind, Alexander;Wolf, Eckhard;Saur, Dieter;Schnieke, Angelika   +1 more
core   +1 more source

Spindle Cell Fibromatosis of the Breast: A Lesson in Malignancy Mimicry

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Spindle cell fibromatosis of the breast (SCFB) is a rare benign tumor that closely mimics malignancy on imaging and clinical examination. Accurate diagnosis relies on histopathology and immunohistochemistry, particularly β‐catenin staining, to guide appropriate management and avoid overtreatment while addressing its locally aggressive behavior
Valerie Fiore, Marc Knezevic‐Maragh, Jovia Williams, Caleb Bonsu, Oluwatito Roberts, Sharon Koehler   +5 more
wiley   +1 more source

Sodium Butyrate Attenuates Sevoflurane‐Induced Impaired Myelination and Neurobehavioral Deficits in Neonatal Mice via the H3K9ac/BDNF/TrkB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Repeated exposure to sevoflurane in neonatal mice leads to impaired myelin development and neurobehavioral dysfunction, a process closely associated with reduced butyrate levels in vivo. Sodium butyrate supplementation effectively ameliorates these sevoflurane‐induced abnormalities by downregulating HDAC3 and HDAC8 expression, enhancing H3K9ac levels ...
Chang Liu, Xinyao Bai, Xinyue Liu, Jinjie Li, Ruizhu Liu, Jinlan Jiang, Guoqing Zhao   +6 more
wiley   +1 more source