Results 111 to 120 of about 33,043 (222)

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Familial Adenomatous Polyposis

Menon G, Kasi A.
europepmc   +2 more sources

Double frameshift mutations in APC and MSH2 in the same individual [PDF]

, 2018
Heterozygous germline DNA mismatch repair gene mutations are typically associated with HNPCC. Here we report the case of a proband whose father was known for familial adenomatous polyposis. The number of polyps (
Arrigoni, Eviano, Berthod, Claudine, Blouin, Jean-Louis, Bründler, Marie-Anne, DeLozier, Celia, Dobbie, Zuzana, Foulkes, William, Hutter, Pierre, Soravia, Claudio   +8 more
core   +1 more source

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, Volume 117, Issue 5, Page 1199-1208, May 2026.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, Volume 117, Issue 5, Page 1209-1222, May 2026.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source

Investigation of Mutation in a Part of Exon 15 of APC Gene in Patients with Familial Adenomatous Polyposis in Gilan Province

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Familial adenomatous polyposis (FAP) is a colorectal cancer caused by the mutation in the APC gene, inherited as an autosomal dominant.
M Ahmad Sharbafi, N Ranji
doaj  

Colorectal Cancer: Epidemiological Trends, Screening, and Inheritability [PDF]

, 2018
Colorectal cancer is one of the most common cancer worldwide. The incidence and mortality trend in different areas of the world varies. Colorectal cancer incidence and mortality are increasing in some countries.
Maulahela, H. (Hasan), Paramita, I. A. (Isabela), Winston, K. (Kevin)   +2 more
core  

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

A Rare Case of Familial Adenomatous Polyposis in South Eastern Nigeria: A Case Report and Review of the Literature

International Journal of Medicine and Health Development
Familial adenomatous polyposis syndrome (FAP) is a rare multisystemic disorder that affects individuals who have mutation in the adenomatous polyposis coli (APC) gene.
Kenneth A. Agu, Jude K. Ede, EvanTherese Nwosu, Ikechukwu S. Eze, Emeka Eze, Chukwuemelie B. Okechukwu, Ifeoma Madichie   +6 more
doaj   +1 more source

Intramucosal Colon Cancer Developing in an Inverted Hyperplastic Polyp

Gut and Liver, 2013
Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis with fewer than one hundred colorectal polyps and a later age of onset of the cancer. Here, we report two cases of AFAP within family members.
doaj   +1 more source