Results 1 to 10 of about 34,604,755 (154)

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1 [PDF]

Molecular Brain, 2023
Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-type calcium ...
Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch   +10 more
doaj   +2 more sources

Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice [PDF]

The Journal of Headache and Pain, 2023
Background Cortical spreading depolarization (CSD), the neurophysiological correlate of the migraine aura, can activate trigeminal pain pathways, but the neurobiological mechanisms and behavioural consequences remain unclear. Here we investigated effects
Anisa Dehghani, Maarten Schenke, Sandra H. van Heiningen, Hulya Karatas, Else A. Tolner, Arn M. J. M. van den Maagdenberg   +5 more
doaj   +2 more sources

CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury [PDF]

eLife, 2022
Patients suffering from familial hemiplegic migraine type 1 (FHM1) may have a disproportionally severe outcome after head trauma, but the underlying mechanisms are unclear. Hence, we subjected knock-in mice carrying the severer S218L or milder R192Q FHM1
Nicole A Terpolilli, Reinhard Dolp, Kai Waehner, Susanne M Schwarzmaier, Elisabeth Rumbler, Boyan Todorov, Michel D Ferrari, Arn MJM van den Maagdenberg, Nikolaus Plesnila   +8 more
doaj   +2 more sources

Familial Hemiplegic Migraine Type 1 Associated with Parkinsonism: A Case Report [PDF]

Case Reports in Neurology, 2015
Familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6) are allelic disorders caused by mutations in the CACNA1A gene on chromosome 19p13.
Marie Bruun, Lena Elisabeth Hjermind, Carsten Thomsen, Else Danielsen, Lise Lykke Thomsen, Lars Hageman Pinborg, Nastaran Khabbazbavani, Joergen Erik Nielsen   +7 more
doaj   +2 more sources

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α₂ Isoform Na,K-ATPase Mutation. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim The Na,K‐ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine‐related mutation, G301R, of the Na,K‐ATPase α2 isoform (α2+/G301R) demonstrated altered metabolism in the heart.
Staehr C, Nguyen TD, Pedersen TM, Vendelbo M, Beck HC, Kjolby M, Rajanathan R, Bouzinova EV, Jessen N, Jeppesen PB, Chibalin AV, Matchkov VV.   +11 more
europepmc   +2 more sources

Cerebellar Atrophy and Changes in Cytokines Associated with the CACNA1A R583Q Mutation in a Russian Familial Hemiplegic Migraine Type 1 Family [PDF]

Frontiers in Cellular Neuroscience, 2017
Background: Immune mechanisms recently emerged as important contributors to migraine pathology with cytokines affecting neuronal excitation. Therefore, elucidating the profile of cytokines activated in various forms of migraine, including those with a ...
Svetlana F. Khaiboullina, Elena G. Mendelevich, Leyla H. Shigapova, Elena Shagimardanova, Guzel Gazizova, Alexey Nikitin, Ekaterina Martynova, Yuriy N. Davidyuk, Enver I. Bogdanov, Oleg Gusev, Oleg Gusev, Oleg Gusev, Arn M. J. M. van den Maagdenberg, Rashid A. Giniatullin, Rashid A. Giniatullin, Albert A. Rizvanov   +15 more
doaj   +2 more sources

A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating [PDF]

Molecular Brain
P/Q-type (Cav2.1) calcium channels mediate Ca2+ influx essential for neuronal excitability and synaptic transmission. The CACNA1A gene, encoding the Cav2.1 pore forming subunit, is highly expressed throughout the mammalian central nervous system ...
Anne-Sophie Sack, Gennerick J. Samera, Anna Hissen, Robert J. Wester, Esperanza Garcia, Paul J. Adams, Terrance P. Snutch   +6 more
doaj   +2 more sources

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment. [PDF]

MedComm (2020)
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Lu W, Zhang Y, Shi C, Tao Y, Li S, Sun Y, Ji F, Jiang D, Snutch TP, Tao J.   +9 more
europepmc   +2 more sources

New Nonsense Variant c.2983G>T; p.Glu995* in the Gene Causes Progressive Autosomal Dominant Ataxia [PDF]

Journal of Movement Disorders, 2021
The genetic testing of hereditary ataxias includes screening for CAG-repeat expansions as well as pathogenic variants and nontranslated oligonucleotide expansion, which can cause spinocerebellar ataxia (SCA).
Yannic Saathoff, Saskia Biskup, Claudia Funke, Christian Roth   +3 more
doaj   +1 more source

Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine

Metabolites, 2022
Metabolite levels in peripheral body fluids can correlate with attack features in migraine patients, which underscores the potential of plasma metabolites as possible disease biomarkers.
Inge C. M. Loonen, Isabelle Kohler, Mohan Ghorasaini, Martin Giera, Arn M. J. M. van den Maagdenberg, Oleg A. Mayboroda, Else A. Tolner   +6 more
doaj   +1 more source