Results 31 to 40 of about 34,604,755 (154)

Association analysis of chromosome 1 migraine candidate genes

BMC Medical Genetics, 2007
Background Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci.
MacMillan John, Colson Natalie J, Ovcaric Micky, Curtain Robert P, Fernandez Francesca, Griffiths Lyn R   +5 more
doaj   +1 more source

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na⁺,K⁺-ATPase α₂-Isoform

Cells, 2023
Two α-isoforms of the Na+,K+-ATPase (α1 and α2) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility.
Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov   +8 more
doaj   +1 more source

Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: A Fos protein study

Neurobiology of Disease, 2014
Familial hemiplegic migraine type 1 (FHM-1) is a monogenic subtype of migraine with aura caused by missense mutations in the CACNA1A gene, which encodes the pore-forming α1 subunit of voltage-gated neuronal CaV2.1 (P/Q-type) calcium channels.
JungWook Park, HeuiSoo Moon, Simon Akerman, Philip R. Holland, Michele P. Lasalandra, Anna P. Andreou, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Peter J. Goadsby   +8 more
doaj   +1 more source

Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT₁ receptor signaling

Molecular Pain, 2008
Background The aberrant release of the neurotransmitters, glutamate and calcitonin-gene related peptide (CGRP), from trigeminal neurons has been implicated in migraine.
Hurley Joyce H, Richter Judith A, Xiao Yan   +2 more
doaj   +1 more source

RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice [PDF]

, 2014
Background Various CACNA1A missense mutations cause familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of migraine with aura. FHM1 mutation R192Q is associated with pure hemiplegic migraine, whereas the S218L mutation causes hemiplegic ...
Koelewijn, S., Frants, R., Boer, J.M., Ferraro, M., Koelewijn, S.C., Hoen, P.A.C. 't, Boer, J., Broos, L., Thoen, P., Ferrari, M.D., De Vries, B., Broos, L.A.M., Vries, B. de, Eising, E., Todorov, B., Maagdenberg, A.M.J.M. van den, Frants, R.R., Van Den Maagdenberg, A.   +17 more
core   +1 more source

Epilepsy in patients with familial hemiplegic migraine

, 2021
Objective: : The coexistence of epilepsy in familial hemiplegic migraine (FHM) has not been reviewed systematically. We investigated the associations of epilepsy in patients with FHM with CACNA1A, ATP1A2, SCN1A or PRRT2 mutations along with clinical and ...
Eser, Metin, Kemal Tutkavul, Tutkavul, Kemal, Hasırcı Bayır, Buse Rahime, Metin Eser, Betül Baykan, Buse Rahime Hasırcı Bayır, Baykan, Betül   +7 more
core   +1 more source

Framework for headache management in pediatric patients with stroke and cerebrovascular lesions: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland, Samuel J. Belfer, Christine K. Fox, Samantha L. Irwin, Rachel Vassar, Ann Oh, Sruthi Ilangovan, Amy A. Gelfand   +7 more
wiley   +1 more source

TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine.

PLoS ONE, 2013
Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. Here, we investigated whether, in trigeminal sensory ganglia, cytokines such as TNFα might contribute to a ...
Alessia Franceschini, Sandra Vilotti, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti   +5 more
doaj   +1 more source

Novel Mutation in CACNA1A Associated with Activity-Induced Dystonia, Cervical Dystonia, and Mild Ataxia

Case Reports in Neurological Medicine, 2021
CACNA1A encodes the pore-forming α1 subunit of the neuronal voltage-gated Cav2.1 (P/Q-type) channels, which are predominantly localized at the presynaptic terminals of the brain and cerebellar neurons and play an important role in controlling ...
Benjamin Stampfl, Dominic Fee
doaj   +1 more source

CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]

, 2002
Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core   +1 more source