Results 51 to 60 of about 34,604,755 (154)

Epilepsy: Molecular Pathogenesis and Emerging Therapies

MedComm, Volume 7, Issue 4, April 2026.
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang, Jiabin Zong, Yu Zhang, Ming Li, Songqing Pan, Zheman Xiao   +5 more
wiley   +1 more source

The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1).

PLoS ONE, 2013
A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 receptors ...
Swathi K Hullugundi, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri   +3 more
doaj   +1 more source

Retrospective analysis of the tolerability and effectiveness of rimegepant for the acute treatment of migraine in adolescents

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 829-834, April 2026.
Abstract Objective This study aims to evaluate the tolerability and effectiveness of the off‐label use of rimegepant as acute migraine treatment in adolescents. Background Calcitonin gene‐related peptide (CGRP) levels are elevated during migraine attacks.
Konstantinos Tourlas, Sruthi Ilangovan, Chelsea White, Samantha L. Irwin, Sara Pavitt   +4 more
wiley   +1 more source

Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation

, 2008
The S218L CACNA1A mutation has been previously described in two families with familial hemiplegic migraine. We present three siblings with the mutation with the novel association of childhood seizures, and highlight the dynamic changes seen on ...
Chan, Yee-Cheun, Chew, S.-E., Sharma, V., Ong, B.K.C., Wilder-Smith, Einar, Chew, Soh-Eng, Wilder-Smith, E., Burgunder, Jean-Marc, Sharma, Vijay, Chan, Y.-C., Ong, Benjamin K C, Lam-Mok-Sing, K.M.J., Lam-Mok-Sing, Karen M J, Burgunder, J.-M.   +13 more
core   +1 more source

Associations between stress and migraine and tension-type headache: Results from a school-based study in adolescents from grammar schools in Germany [PDF]

, 2011
Introduction: Stress is considered the major contributor to migraine and tension-type headache in adolescents. Previous studies have focused on general stressors, whereas the aim of the present study was to investigate associations between individuals ...
Straube, Andreas, Kries, Rüdiger von, Heinen, Florian, Astrid Milde-Busch, Florian Heinen, Rüdiger von Kries, Milde-Busch, Astrid, Astrid Blaschek, Christoph Schankin, Ingo Borggräfe, Inga Koerte, Andreas Straube, Schankin, Christoph, Blaschek, Astrid, Koerte, Inga, Borggräfe, Ingo   +15 more
core   +1 more source

Large-Scale Functional RNAi Screen in Identifies TGF-β and Notch Signaling Pathways as Modifiers of

ASN Neuro, 2016
Variants in CACNA1A that encodes the pore-forming α 1 -subunit of human voltage-gated Cav2.1 (P/Q-type) Ca 2+ channels cause several autosomal-dominant neurologic disorders, including familial hemiplegic migraine type 1, episodic ataxia type 2, and ...
Maria da Conceição Pereira, Sara Morais, Jorge Sequeiros, Isabel Alonso   +3 more
doaj   +1 more source

Efficacy and safety of rimegepant for the acute treatment of migraine in Black or African American adults: A post hoc pooled subgroup analysis from three randomized, placebo‐controlled clinical trials

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 874-884, April 2026.
Abstract Objective This post hoc subgroup analysis was conducted using pooled data from three US‐based clinical trials to compare efficacy and safety of rimegepant 75 mg versus placebo in acute migraine in adults who are Black or African American.
Larry Charleston IV, Cynthia E. Armand, Teshamae S. Monteith, Hope L. O'Brien, Chandra C. Abbott, Glenn C. Pixton, Terence Fullerton   +6 more
wiley   +1 more source

Coexisting typical migraine in familial hemiplegic migraine

, 2010
In contrast to patients with migraine with aura (MA) and migraine without aura (MO), most patients with familial hemiplegic migraine (FHM) do not report migraine-like attacks after pharmacologic provocation with glyceryl trinitrate (GTN), a donor of ...
Hansen, Jakob Møller, Ashina, Messoud, Thomsen, Lise Lykke, Olesen, Jes   +3 more
core   +1 more source

Familial Hemiplegic Migraine Type 3 (FHM3) With an SCN1A Mutation in a Chinese Family: A Case Report [PDF]

, 2018
Familial hemiplegic migraine (FHM) is a rare, monogenic, autosomal dominant subtype of migraine, in which three genes, CACNA1A, ATP1A2, and SCN1A, are currently known to be involved.
Hongmei Meng, Na Shao, Wuqiong Zhang, Haining Zhang, Xue Wang, Miaomiao Yu   +5 more
core   +1 more source

Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway.

PLoS Genetics, 2018
Gain-of-function mutations in the human CaV2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by CaV2.1 gains of function, we engineered mutations encoding FHM1 amino-acid ...
Douglas J Brusich, Ashlyn M Spring, Thomas D James, Catherine J Yeates, Timothy H Helms, C Andrew Frank   +5 more
doaj   +1 more source