Results 81 to 90 of about 18,073,437 (258)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Work-family conflict in Europe. A focus on the heterogeneity of self-employment
, 2021 This article aims at analysing how subjective work-family conflict is experienced by different self-employed men and women in comparison to employees and informal workers in Europe.
Murgia A., Bozzon R.
core +1 more source
Job Demands, Engagement, and Turnover Intentions in Polish Nurses: The Role of Work-Family Interface
Frontiers in Psychology, 2016 Background: Poland has lower ratios of employed registered nurses per 1,000 inhabitants than the EU average. Polish nurses work under miserable conditions without assisting personnel, and they reconcile their professional demands with responsibilities ...
Anna Maria Dåderman +2 more
doaj +1 more source
Crossover of the dimensions of work-family and family-work conflict in couples: Protocol for a qualitative study. [PDF]
PLoS One, 2023 Smoktunowicz E +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Family-Work Conflict and Successful Aging at Work of Employees in Manufacturing Enterprises in North China. [PDF]
Psychol Res Behav Manag, 2023 Ma H, Zhao C.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The integrative relationship between work–family conflict and turnover intention: a meta-analysis
Frontiers in Public HealthThe impact of work–family conflict on employee turnover intention has become a significant topic in organizational behavior research. However, existing findings show significant discrepancies, lacking systematic quantitative integration.
Guanghua Li +5 more
doaj +1 more source
Pengaruh Dukungan Supervisor Terhadap Work Family Conflict
Wacana: Jurnal Sosial dan Humaniora, 2016 Penelitian empiris di bidang work family conflict (konflik antara kerja dan keluarga) menunjukkan bahwa work family conflict memiliki dampak yang negatif terhadap individu, keluarga dan organisasi.
Wike Wike +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source