Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy
The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro +2 more
wiley +1 more source
FANCD2 associated with sporadic breast cancer risk [PDF]
, 2010 Several components of the Fanconi anaemia (FA) family of proteins allow the formation of the DNA repair complex foci formed by proteins such as BRCA1/2 and RAD51.
Arias, J.I. (José) +6 more
core
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair [PDF]
, 2014 SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia.
Al-Minawi +63 more
core +2 more sources
A Comprehensive Review of Gene Mutations in Inherited Blood Disorders Among the Saudi Population
Human Mutation, Volume 2026, Issue 1, 2026.Background Inherited blood disorders (IBDs) are a major health concern in the Kingdom of Saudi Arabia (KSA), largely due to the high prevalence of consanguineous marriages. Objectives This review is aimed at summarizing gene mutations and variants associated with IBDs in the Saudi population to enhance diagnosis and personalized care. Methods Published
Nancy S. Younis +12 more
wiley +1 more source
Metastasis-inducing proteins are widely expressed in human brain metastases and associated with intracranial progression and radiation response [PDF]
, 2016 Background:Understanding the factors that drive recurrence and radiosensitivity in brain metastases would improve prediction of outcomes, treatment planning and development of therapeutics.
Brodbelt, A +8 more
core +1 more source
A novel duplication polymorphism in the FANCApromoter and its association with breast and ovarian cancer [PDF]
, 1997 The FANCA gene is one of the genes in which mutations lead to Fanconi anaemia, a rare autosomal recessive disorder characterised by congenital abnormalities, bone marrow failure, and predisposition to malignancy.
Alexander Dobrovic +5 more
core +4 more sources
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. [PDF]
, 2017 Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation group C (FANCC), a gene encoding a
Bock, Christoph +15 more
core +2 more sources
DNA repair in cancer: emerging targets for personalized therapy [PDF]
, 2014 Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity.
Abbotts, Rachel +2 more
core +3 more sources
Inflammation targets specific organs for cancer in carriers of BRCA1/2 pathway mutations [PDF]
, 2010 Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed.
Bernard Friedenson
core +1 more source
Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies. [PDF]
, 2017 DNA replication is a highly demanding process regarding the energy and material supply and must be precisely regulated, involving multiple cellular feedbacks.
Chroma, K +3 more
core +2 more sources